Correlation Between Arterial Stiffness and Plasma Endothelin-1 Concentration in Man with Obesity


Background.Obesity is associated with increase arterial stiffness and el-evated plasma endothelin-1 concentration. However, there is still conflict-ing data regarding the effect of obesity on arterial stiffness and plasma endothelin-1 concentration.
Objective.The purpose of the current study was to assess this effect and analyze whether there was correlation between arterial stiffness indices and plasma endothelin-1 concentration.
Methods.The design of the study was cross sectional study that compare and correlate arterial stiffness and plasma endothelin-1 concentration be-tween obesity group (n=40) and normoweight group (n=40). Obesity was defined as body mass index = 25 kg/m2. Arterial stiffness was as-sessed by measuring carotid-femoral pulse wave velocity (PWV) dan ß stiffness index (ß) non-invasively using ultrasound method. Endothelin-1 was measured by ELISA.
Results.There was no significant difference regarding PWV between obesity and normoweight group (mean ± SD: 809.44 ± 137.77 versus 850.96 ± 211.60 cm/s, p=NS), but ßwas significantly higher in obese group (8.79 ± 3.15 versus 7.28 ± 1.96, p=0.012). PWV and ßcorre-lated significantly with age (PWV: r=0.446, p<0.001, ß: r=0.354, p=0.001), but only ßcorrelated with body mass index (r=0.282, p=0.011) and waist circumference (r=0.312, p=0.005). There was no significant difference between obesity and normoweight group regard-ing plasma endothelin-1 concentration (0.94 ± 0.26 versus 0.95 ± 0.18 pg/dl, p=NS). There are no significant correlations between PWV/ßand plasma endothelin-1 concentration.
Conclusions.These findings suggest that the effect of obesity on arterial stiffness is not uniformly seen throughout all arterial region. Obesity im-pact on carotid artery is greater than its impact on aorta, and this impact on arterial stiffness is not mediated by endothelin-1.


Download data is not yet available.


Safar ME, Czernichow S, Blacher J. Obesity, arterial stiffness, and cardiovascular risk. J Am Soc Nephrol. 2006;17:S109-S111.

Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, et al. Obesity and cardiovascular disease : pathophysiology, evaluation, and effect of weight loss : an update of the 1997 american heart association scientific statement on obesity and heart disease from the obesity committee of the council on nutrition, physical activity, and metabolism. Circulation. 2006;113:898-918.

Wilson PWF, D’Agostino, Sullivan L, Parise H, Kannel WB. Overweight and obesity as determinants of cardiovascular risk. Arch Intern Med. 2002;162:1867-1872.

Wildman RP, Mackey RH, Bostom A, Thompson T, Sutton-Tyrrell K. Measures of obesity are associated with vascular stiffness in young and older adults. Hypertension. 2003;42:468-473.

Sutton-Tyrell K, Newman A, Simonsick EM, Havlik R, Pahor M, Lakatta E, Spurgeon H, Vaitkevicius P. Aortic stiffness is associated with visceral adiposity in older adults enrolled in the study of health, aging, and body composition. Hypertension. 2001;38:429-433.

Giltay EJ, Lamber J, Elbers JMH, Gooren LJG, Asscheman H, Stehouwer CDA. Arterial compliance and distensibility are modulated by body composition in both men and women but by insulin sensitivity only in women. Diabetologia. 1999;42:214-221.

MacKenzie IS, Wilkinson IB, Cockroft JR. Assessment of arterial stiffness in clinical practice. Q J Med. 2002;95:67-74.

Gates PE, Tanaka H, Hiatt WR, Seals DR. Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension. Hypertension. 2004;44:35-41.

Bagrov AY, Lakatta EG. The dietary sodium-blood pressure plot “stiffens”. Hypertension. 2004;44:22-24.

Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. JAMA. 1999;282:2131-2135.

Liao D, Arnett DK, Tyroler HA, Riley WA, Chambless LE, Szklo M, Heiss G. Arterial stiffness and the development of hypertension: The ARIC study. Hypertension. 1999;34:201-206.

Zieman S, Melenovsky M, Kass D. Mechanism, patho-physiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005;25:932-943.

Scuteri A, Najjar SS, Muller DC, Andres R, Hougaku H, Metter J, Lakatta EG. Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness. J Am Coll Cardiol. 2004;43:1388-1395.

Safar ME, Levy BI, Struijker-Boudier H. Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation. 2003;107:2864-2869.

McVeigh GE, Bratteli CW, Morgan DJ, Alinder CM, Glasser SP, Finkelstein SM, Cohn JN. Age-related abnormalities in arterial compliance identified by pressure pulse contour analysis. Hypertension. 1999;33:1392-1398.

Franklin SS, Khan SA, Wong ND, Larson MG, Levy D. Is pulse pressure useful in predicting risk for coronary heart disease : The Framingham Heart Study. Circulation. 1999;100:354-360.

Stefanadis C, Dernellis J, Tsiamis E, Stratos C, Diamantopoulos L, Michaelides A, Toutouzas P. Aortic stiffness as a risk factor for recurrent acute coronary events in patients with ischaemic heart disease. Eur Heart J. 2000;21:390-396.

Vaccarino V, Holford TR, Lakatta EG. Pulse pressure and risk for myocardial infarction and heart failure in the elderly. J Am Coll Cardiol. 2000;36:130-138.

Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, Ducimetiere P, Benetos A. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension. 2001;37:1236-1241.

Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B, Boutouyrie P. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke. 2003;34:1203-1206.

Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance. Circulation. 2002;106:2085-2090.

Khattar RS, Swales JD, Dore C, Senior R, Lahiri A. Effect of aging on the prognostic significance of ambulatory systolic, diastolic, and pulse pressure in essential hypertension. Circulation. 2001;104:783-789.

Weber T, Auer J, O’Rourke MF, Kvas E, Lassnig E, Berent R, Eber B. Arterial stiffness, wave reflections and the risk of coronary artery disease. Circulation. 2004;109:184-189.

Safar ME, Blacher J, Pannier B, et al. Central pulse pressure and mortality in end-stage renal disease. Hypertension. 2002;39:735-738.

Wildman RP, Farhat GN, Patel AS, Mackey RH, Brockwell S. Weight change is associated with change in arterial stiffness among healthy young adults. Hypertension. 2005;45:187-192.

Sjostrom CD, Peltonen M, Sjostrom L. Blood pressure and pulse pressure during long-term weight loss in the obese: the swedish obese subjects (SOS) intervention study. Obesity Research. 2001;9:188-195.

Sengstock DM, Vaitkevicius P, Supiano MA. Arterial stiffness is related to insulin resistance in nondiabetic hypertensive older adults. J Clin Endocrinol Metab. 2005;90:2823-2827.

Westerbacka J, Seppala-Lindroos A, Yki-Jarvinen H. Resistance to acute insulin induced decreases in large artery stiffness accompanies the insulin resistance syndrome. J Clin Endocrinol Metab. 2001;86:5262-5268.

Tamminen M, Westerbacka J, Vehkavaara S, Yki-Jarvinen H. Insulin-induced decreases in aortic wave reflection and central systolic pressure are impaired in type 2 diabetes. Diabetes Care. 2002;25:2314-2319.

Brands MW, Hall JE. Insulin resistance, hyperinsulinemia and obesity-associated hypertension. J Am Soc Nephrol. 1992;3:1064-1077.
Views & Downloads
Abstract views: 107   
PDF (Bahasa Indonesia) downloads: 10   
How to Cite
Correlation Between Arterial Stiffness and Plasma Endothelin-1 Concentration in Man with Obesity. (1). Indonesian Journal of Cardiology, 28(4), 237-245.
Clinical Research