Correlation of Tumor Necrosis Factor with Left Ventricular Hypertrophy and Prehypertension in Non Diabetes Male Abdominal Obesity

Abstract

Introduction : Left Ventricular Hypertrophy (LVH) as an independent
predictor of mortality may develop in non diabetes obese. There’s a role
of inflammation because adipose tissue release the proinflammatory cytokines
such as TNF ?. It is important to prove this inflammatory state and
its impact to the healthy obese for preventing cardiovascular events in the
future. Purpose of this study is to investigate correlation of TNF ? level
with LVH and Prehypertension in non diabetes abdominal obesity.
Methods : Eighty-two male abdominal obesity and non abdominal obesity
subjects with no history of diabetes were recruited in this cross-sectional
study. Tumor Necrosis Factor Alpha level were measured with radioimmunoassay,
blood pressure measurement was taken 2 times. Left Ventricular
Mass Index(LVMI) were evaluated by M-Mode and two dimension
echocardiogram and value above 115 g/m2 are indicative of LVH.
Result : TNFa alpha level is higher in abdominal obesity group as compare
to non abdominal obesity (0,7133+0,2072 pg/ml vs 2,395+1,5371 pg/ml,
p<0,001). Most of obese subjects developed prehypertension. Subjects
with prehypertension showed higher plasma TNF alpha level as compare to
subject with normal blood pressure (2,83+1,649 pg/ml vs 1,38 + 0,3245
pg/ml, p<0,001). We also found the LVH in 30 (60%) of abdominal obesity
subjects. Obese subject had larger LVMI than non obese (138,427+47,461
g/m2 vs 90,188+16,06 g/m2, p<0,001), and correlates positively to plasma
TNF alpha level (r=0,727, p,<0,001).
Conclusion : High level of plasma TNF alpha is associated with left ventricular
hypertrophy and prehypertension in non diabetes male abdominal
obesity.

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Published
2015-03-31
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How to Cite
Correlation of Tumor Necrosis Factor with Left Ventricular Hypertrophy and Prehypertension in Non Diabetes Male Abdominal Obesity. (2015). Indonesian Journal of Cardiology, 34(4), 231-6. https://doi.org/10.30701/ijc.v34i4.381
Section
Clinical Research