Secretory Phospholipase A2 Tipe Ii (Spla Ii) pada Penyakit Kardiovaskuler

Abstract

Reaksi inflamasi berperan dalam beberapa pathogenesis kondisi kardiovaskuler seperti atherosklerosis dan kerusakan iskemik
pada infark miokard akut (IMA). Di antara mediator-mediator yang terlibat dalam inflamasi tersebut adalah enzim secretory
phospholipase A2 tipe II (sPLA2-II). Meskipun beberapa sel memang memproduksi sPLA2-II, namun sintesis oleh sel-sel tertentu
seperti hepatosit, adalah khas sebagai reaktan fase akut. Literatur terbaru menyatakan banyaknya peran dari sPLA2-II dalam
penyakit kardiovaskuler. Dalam tulisan berikut, akan mendiskusikan peran sPLA2-II dalam berbagai model atherosklerosis
atau IMA, baik in vitro maupun in vivo, termasuk perspektif terapeutik dari sPLA2-II inhibitor. Disimpulkan bahwa sPLA2-II
merupakan mediator inflamasi yang penting dalam penyakit kardiovaskuler.

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Sargowo D: Spla Ii pada Penyakit Kardiovaskular
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Published
2015-04-01
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How to Cite
Secretory Phospholipase A2 Tipe Ii (Spla Ii) pada Penyakit Kardiovaskuler. (2015). Indonesian Journal of Cardiology, 34(4), 271-9. https://doi.org/10.30701/ijc.v34i4.386
Section
Review Article