Neurohormonal Activation and Left Atrium Remodeling in Mitral Stenosis

  • Vidya Gilang Rejeki Departemen Kardiologi dan Vaskular Universitas Indonesia / RSJPD Harapan Kita
  • Bambang Budi Siswanto Departemen Kardiologi dan Vaskular Universitas Indonesia / RSJPD Harapan Kita
  • Nani Hersunarti Departemen Kardiologi dan Vaskular Universitas Indonesia / RSJPD Harapan Kita
Keywords: Left Atrial Neurohormonal activation, Left Atrial Remodeling, Mitral Stenosis

Abstract

Mitral stenosis is closely related with the hemodynamic consequences of obstructed mitral leaflet. Definitive therapy in mitral stenosis is mechanical intervention. Late presentation of mitral stenosis patients to medical facilities due to limited health facilities and Indonesians demographic, often make patients condition deteriorates, in which intervention need to be delayed or even no longer suitable. Stretched left atrium and reduced cardiac output stimulate several neurohormonal activation; renin-angiotensin-aldosterone and symphatetic nervous system. Left atrial remodeling further worsen hemodynamic ststus. Renin-angiotensin-aldosterone and sympathetic blockage could improve mitral stenosis patients condition with close observation to hypotension status.

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Published
2017-01-24

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How to Cite
Rejeki, V., Siswanto, B., & Hersunarti, N. (2017). Neurohormonal Activation and Left Atrium Remodeling in Mitral Stenosis. Indonesian Journal of Cardiology, 37(1), 38-46. https://doi.org/10.30701/ijc.v37i1.555
Section
Review Article