Correlation Between Plasma Leptin and Endotelin-1 Plasma Level in Obese Hypertensive Subjects
Abstract
Background.Hypertension is frequently found in obesity, although the mechanisms for obesity related hypertension are still unclear. Several studies showed the role of endothelin-1 in the development of hypertension asso-ciated with obesity. More recent studies showed the possibility for the role of leptin in obesity related hypertension. In vitro study with human umbilical vein endothelial cells (HUVECs) showed correlation between leptin and endothelin-1. The aim of this study was to clarify the relation-ship between leptin, body mass index (BMI), blood pressure (BP) and plasma endothelin-1 in obese hypertensive subjects.Methods.A cross sectional study was performed at National Cardiovas-cular Centre, Harapan Kita Jakarta, which included 80 Indonesian men. The subjects were divided into lean hypertensive and obese hypertensive. The plasma immunoreactive ET-1 and leptin were determined by ELISA method.
Results.ET-1 level and leptin level were significantly higher in obese hy-pertensive subjects compared with lean hypertensive subjects. There are significant correlation between endothelin level with BMI (r = 0.32; p < 0.005). There are also significant correlation between leptin level with BMI (r = 0.533; p <0.01), but there are no correlation between plasma leptin and endothelin-1 level in obese hypertensive men.
Conclusions.Leptin and ET-1 level were significantly increase in obese hypertensive subjects compared with lean hypertensive subjects. There is no correlation between leptin and ET-1 level in obese hypertensive subjects.
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References
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Parrinello G, Scaglione R, Pinto A, Carao S, Cecala M, Di Silvestre G, et al. Central obesity and hypertension, The role of Plasma Endothelin. Am.J.Hypertens 1996;9:1186-91.
Cardillo C, Campia U, Iantorno M, Panza JA. Enhanced Vascular Activity of Endogenous Endothelin-1 in Obese Hypertensive Patients. Hypertension 2004;43: 36-40.
Shek EW, Brands MW, Hall JE. Chronic Leptin Infusion Increases Arterial Pressure. Hypertension 1998; 31: 409-14.
Henriksen JH, Holst JJ, Moller S, Andersen UB, Bendtsen F, Jensens G. Elevated Circulating Leptin Levels in Arterial Hypertension: Relationship to Arteriovenous Overflow and Extraction of Leptin. Clinical Science 2000;99:527-34
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Adiarto S, Emoto N, Iwasa N, Yokoyama M. Obesity-induced upregulation of myocardial endothelin-1 expression is mediated by leptin.Biochemical and Biophysical Res Comm 2007; 353:623-7
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Rahmouni K, Correia MLG, Haynes WG, Mark AL. Obesity-Associated Hpertension: New Insights Into Mechanism. Hypertension. 2005; 45 : 9-14
Kannel W. Lipids, diabetes and coronary heart disease : Insights from the Framingham Heart Study. Am Heart J. 1985; 110:1100-07
Sowers JR. Obesity and cardiovascular disease. Clinical Chemistry 1998;44:1821-25.
Kannel WB, Garrison RJ, Dannenberg AL. Selular Blood Pressure trends in normotensive persons. Am.Heart J 1993;125:1154-58
Wilson PWF, Águstino RB, Sullivan L, Parise H, Kannel WB. Overweight and obesity as determinants of cardiovascular risk. The Framingham Experience. Arc.Intern.Med.2002;162: 1867-72
Aneja A, El-Atat F, McFarlane S, Sowers JR. Hypertension and obesity. Endo Jnls 2004;169-205
Kissebah AH, Krakower GR. Regional adiposity and morbidity. Physiol Rev 1994;74:761-811
Poirir P, Giles TD, Bray GA, Hong Y, Stern JS, Sunyer XP, et al. Obesity and cardiovascular disease: Pathophysiology, Evaluation, and effect of weight loss. Arterioscler.Thromb. Vasc.Biol. 2006;26;968-976.
Inoue S, Zimmet P, Caterson I, Chunming C, Ikeda Y, Khalid AK, et al. The Asia Pasific perspective : Redefining Obesity and its treatment 2000
Mazuo K, Mikami H, Ogihara, Tuck ML. Weight Gain-Induced Blood Pressure Elevation. Hypertension 2000;35:1135-40
Barton M, Carmona R, Ortmann J, Krieger J.E, Traupe T. Obesity associated activation of Angiotensin and Endothelin in Cardiovascular system. The International Journal of Biochemistry & Cell Biology, 2003:826-837
Wang M, Lee y, Unger R. Novel form of lipolysis induced by leptin. J Biol Chem 1999;274(25):1741-4
Fruhbeck G, Aguado M, Martinez J. In vitro lipolytic effect of leptin on mouse adipocytes : evidence for a possible autocrine/paracrine role of leptin. Biochem Biophys Res Commun. 1997;240(3):590-4
Siegrist-Kaiser C, PauliV, Juge-Aubry C, Bross O, Pernia A, Chin W, et al. Direct effects of leptin on brown and white adipose tissue. J Clin Invest 1997;100(11): 2858-64
Ergull S, Parish DC, Puett D, Ergul A. Racial Differences in Plasma Endotelin-1 concentration in Individual with Essential Hypertension. Hypertension 1996;28: 652-55.
Parrinello G, Scaglione R, Pinto A, Carao S, Cecala M, Di Silvestre G, et al. Central obesity and hypertension, The role of Plasma Endothelin. Am.J.Hypertens 1996;9:1186-91.
Cardillo C, Campia U, Iantorno M, Panza JA. Enhanced Vascular Activity of Endogenous Endothelin-1 in Obese Hypertensive Patients. Hypertension 2004;43: 36-40.
Shek EW, Brands MW, Hall JE. Chronic Leptin Infusion Increases Arterial Pressure. Hypertension 1998; 31: 409-14.
Henriksen JH, Holst JJ, Moller S, Andersen UB, Bendtsen F, Jensens G. Elevated Circulating Leptin Levels in Arterial Hypertension: Relationship to Arteriovenous Overflow and Extraction of Leptin. Clinical Science 2000;99:527-34
Quehenberger P, Exner M, Plassmann RS, Ruzicka K, Bieglmayer C, Endler G, et al. Leptin Induces Endothelin-1 in Endothelial Cells in Vitro. Circ Res 2002;90:711-8
Adiarto S, Emoto N, Iwasa N, Yokoyama M. Obesity-induced upregulation of myocardial endothelin-1 expression is mediated by leptin.Biochemical and Biophysical Res Comm 2007; 353:623-7
Chobanian A.V., Bakris G.L., Black H.R., Cushman W.C., Green L.A., Izzo J.L., Jones D.W., Materson B.J., Oparil S, Wright J.T., Rocella E.J., and The National High Blood Pressure Education Program Coordinating Committee.
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How to Cite
Rahayoe, A., & Andriantoro, H. (1). Correlation Between Plasma Leptin and Endotelin-1 Plasma Level in Obese Hypertensive Subjects. Indonesian Journal of Cardiology, 28(4), 246-255. https://doi.org/10.30701/ijc.v28i4.228
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