Gap Junctions in Ischemia-Related Ventricular Arrhythmia
AbstractCardiovascular diseases are the leading cause of death worldwide, with isch-emic heart disease being the most common entity. Ventricular arrhythmia is one of the complications of ischemia that can result in sudden cardiac death. One of the underlying mechanisms of ischemia induced arrhythmia is closure of cardiac myocytes gap junctions, where gap junctions are channel-like structure between cells that allow passage of molecules and electrical current. During ischemia, gap junctions close incompletely, creating tissue impedance heterogeneity and conduction slowing, which provide substrate for ventricular arrhythmia. Conditions where gap junctions structure is altered, such as in heart failure, is associated with increased vulnerability of ischemia-induced ventricular arrhythmia.
Zipes DP, Wellens HJ. Sudden cardiac death. Circulation. 1998;98:2334-2351
Medline. Medical subject heading. 2010;2010
Delmar M, Duffy HS, Sorgen PL, Taffet SM, Spray DC. Mo-lecular organization and regulation of the cardiac gap junction channel connexin43 In: Zipes DP, Jalife J, eds. Cardiac electro-physiology: From cell to bedside. Saunders; 2004.
Revel JP, Karnovsky MJ. Hexagonal array of subunits in in-tercellular junctions of the mouse heart and liver. J Cell Biol.1967;33:C7-C12
Perkins G, Goodenough D, Sosinsky G. Three-dimensional structure of the gap junction connexon. Biophys J. 1997;72:533
Duffy HS. Cardiac connections--the antiarrhythmic solution? N Engl J Med. 2008;358:1397-1398
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