Gap Junctions in Ischemia-Related Ventricular Arrhythmia

  • Berlian Idriansyah Idris Department of Cardiology and Vascular Medicine Faculty of Medicine, University of Indonesia National Cardiovascular Center Harapan Kita, Jakarta
  • Yoga Yuniadi Department of Cardiology and Vascular Medicine Faculty of Medicine, University of Indonesia National Cardiovascular Center Harapan Kita, Jakarta

Abstract

Cardiovascular diseases are the leading cause of death worldwide, with isch-emic heart disease being the most common entity. Ventricular arrhythmia is one of the complications of ischemia that can result in sudden cardiac death. One of the underlying mechanisms of ischemia induced arrhythmia is closure of cardiac myocytes gap junctions, where gap junctions are channel-like structure between cells that allow passage of molecules and electrical current. During ischemia, gap junctions close incompletely, creating tissue impedance heterogeneity and conduction slowing, which provide substrate for ventricular arrhythmia. Conditions where gap junctions structure is altered, such as in heart failure, is associated with increased vulnerability of ischemia-induced ventricular arrhythmia.

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References

World Health Organization. The global burden of disease: 2004 update. 2008

Zipes DP, Wellens HJ. Sudden cardiac death. Circulation. 1998;98:2334-2351

Medline. Medical subject heading. 2010;2010

Delmar M, Duffy HS, Sorgen PL, Taffet SM, Spray DC. Mo-lecular organization and regulation of the cardiac gap junction channel connexin43 In: Zipes DP, Jalife J, eds. Cardiac electro-physiology: From cell to bedside. Saunders; 2004.

Revel JP, Karnovsky MJ. Hexagonal array of subunits in in-tercellular junctions of the mouse heart and liver. J Cell Biol.1967;33:C7-C12

Perkins G, Goodenough D, Sosinsky G. Three-dimensional structure of the gap junction connexon. Biophys J. 1997;72:533

Duffy HS. Cardiac connections--the antiarrhythmic solution? N Engl J Med. 2008;358:1397-1398
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How to Cite
Idris, B., & Yuniadi, Y. (1). Gap Junctions in Ischemia-Related Ventricular Arrhythmia. Indonesian Journal of Cardiology, 32(1), 53-60. https://doi.org/10.30701/ijc.v32i1.123
Section
Review Article