Collagen-Based Hydrogel Encapsulated Cardiosphere-Derived Cell (CDC): Potential of Stem Cells as Tissue Repair Therapy Post-Acute Myocardial Infarction
Potential of Stem Cells as Tissue Repair Therapy Post-Acute Myocardial Infarction
Keywords:
acute myocardial infarction, cardiosphere-derived cell, collagen, hydrogel
Abstract
Acute myocardial infarction (AMI) is a global health issue that is the leading cause of morbidity and mortality. Post-AMI management currently has therapeutic and side effect limitations, and has not been able to repair damage to myocardial tissue caused by AMI. The development and discovery of therapeutic modalities with the potential for a more optimal therapeutic effect remains a challenge in this post-AMI treatment. The purpose of this literature review is to collect and analyze various sources related to collagen-based hydrogel encapsulated cardiosphere-derived cell (CDC). This literature review is written systematically by gathering library sources from various search engines, such as Google Scholar, PubMed, and Research Gate. According to the findings of the study, CDC has the potential to be used as a post-AMI therapy because it can promote regeneration of the heart, which has lost function as a result of the AMI. To achieve the greatest effect, this modality is administered intracoronary. This modality will be encapsulated with collagen hydrogel, which has a cardioprotective effect, in order to increase the survival and effectiveness of CDC. The use of collagen-based hydrogel encapsulated CDC can provide post-AMI cell regeneration effects comparable to existing modalities while having minimal side effects. Further investigation in larger and more definitive trials is needed to elucidate the potential use of CDC therapy in AMI.
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References
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2. Jayaraj JC, Davatyan K, Subramanian SS, Priya J. Epidemiology of Myocardial Infarction. Minerva Med. 2018;54:2083-2087.
3. Mboi N, Murty Surbakti I, Trihandini I, Elyazar I, Houston Smith K, Bahjuri Ali P, et al. On the road to universal health care in Indonesia, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet (London, England). 2018;392:581-591.
4. Isted A, Williams R, Oakeshott P. Secondary prevention following myocardial infarction: a clinical update. Br J Gen Pract. 2018;68:151.
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6. Leong YY, Ng WH, Ellison-Hughes GM, Tan JJ. Cardiac Stem Cells for Myocardial Regeneration: They Are Not Alone. Front Cardiovasc Med. 2017;4:47.
7. Gallet R, Dawkins J, Valle J, Simsolo E, De Couto G, Middleton R, Tseliou E, Luthringer D, Kreke M, Smith RR, Marbán L, Ghaleh B, Marbán E. Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction. Eur Heart J. 2017;38:201-211.
8. Ashur C, Frishman WH. Cardiosphere-Derived Cells and Ischemic Heart Failure. Cardiol Rev. 2018;26:8-21.
9. Hastings CL, Roche ET, Ruiz-Hernandez E, Schenke-Layland K, Walsh CJ, Duffy GP. Drug and cell delivery for cardiac regeneration. Adv Drug Deliv Rev. 2015;84:85-106.
10. Smith RR uckdesche., Marbán E, Marbán L. Enhancing retention and efficacy of cardiosphere-derived cells administered after myocardial infarction using a hyaluronan-gelatin hydrogel. Biomatter. 2013;3.
11. Zhang Y, Zhu D, Wei Y, Wu Y, Cui W, Liuqin L, Fan G, Yang Q, Wang Z, Xu Z, Kong D, Zeng L, Zhao Q. A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model. Acta Biomater. 2019;86:223-234.
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13. Minelli S, Minelli P, Montinari MR. Reflections on Atherosclerosis: Lesson from the Past and Future Research Directions. J Multidiscip Healthc. 2020;13:621.
14. Kumar V, Abbas A, Aster J. Robbins Basic Pathology E-Book. Elsevier Heal Sci. 2017:133-142.
15. Ojha N, Dhamoon AS. Myocardial Infarction. StatPearls. August 2021.
16. Heusch G, Gersh BJ. The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge. Eur Heart J. 2017;38:774-784.
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18. Mirotsou M, Jayawardena TM, Schmeckpeper J, Gnecchi M, Dzau VJ. Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol. 2011;50:280-289.
19. Li T-S, Cheng K, Malliaras K, Smith RR, Zhang Y, Sun B, Matsushita N, Blusztajn A, Terrovitis J, Kusuoka H, Marbán L, Marbán E. Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol. 2012;59:942-953.
20. Walravens A-S, Smolgovsky S, Li L, Kelly L, Antes T, Peck K, Quon T, Ibrahim A, Marbán E, Berman B, Marbán L, R-Borlado L, de Couto G. Mechanistic and therapeutic distinctions between cardiosphere-derived cell and mesenchymal stem cell extracellular vesicle non-coding RNA. Sci Rep. 2021;11:8666.
21. Sun Y, Chi D, Tan M, Kang K, Zhang M, Jin X, Leng X, Cao R, Liu X, Yu B, Wu J. Cadaveric cardiosphere-derived cells can maintain regenerative capacity and improve the heart function of cardiomyopathy. Cell Cycle. 2016;15:1248-1256.
22. Hensley MT, de Andrade J, Keene B, Meurs K, Tang J, Wang Z, Caranasos TG, Piedrahita J, Li T-S, Cheng K. Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts. J Cell Mol Med. 2015;19:1805-1813.
23. Pagano F, Picchio V, Angelini F, Iaccarino A, Peruzzi M, Cavarretta E, Biondi-Zoccai G, Sciarretta S, De Falco E, Chimenti I, Frati G. The Biological Mechanisms of Action of Cardiac Progenitor Cell Therapy. Curr Cardiol Rep. 2018;20:84.
24. Carr CA, Stuckey DJ, Tan JJ, Tan SC, Gomes RSM, Camelliti P, Messina E, Giacomello A, Ellison GM, Clarke K. Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks - an mri study. PLoS One. 2011;6.
25. Machida M, Takagaki Y, Matsuoka R, Kawaguchi N. Proteomic comparison of spherical aggregates and adherent cells of cardiac stem cells. Int J Cardiol. 2011;153:296-305.
26. Simpson DL, Mishra R, Sharma S, Goh SK, Deshmukh S, Kaushal S. A strong regenerative ability of cardiac stem cells derived from neonatal hearts. Circulation. 2012;126:S46-53.
27. Hoeeg C, Dolatshahi-Pirouz A, Follin B. Injectable Hydrogels for Improving Cardiac Cell Therapy-In Vivo Evidence and Translational Challenges. Gels (Basel, Switzerland). 2021;7.
28. Malliaras K, Marbán E. Cardiac cell therapy: where we’ve been, where we are, and where we should be headed. Br Med Bull. 2011;98:161-185.
29. Li Z, Fan Z, Xu Y, Lo W, Wang X, Niu H, Li X, Xie X, Khan M, Guan J. pH-Sensitive and Thermosensitive Hydrogels as Stem-Cell Carriers for Cardiac Therapy. ACS Appl Mater Interfaces. 2016;8:10752-10760.
30. Cheng K, Li TS, Malliaras K, Davis DR, Zhang Y, Marbán E. Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction. Circ Res. 2010;106:1570-1581.
31. Peña B, Laughter M, Jett S, Rowland TJ, Taylor MRG, Mestroni L, Park D. Injectable Hydrogels for Cardiac Tissue Engineering. Macromol Biosci. 2018;18:e1800079.
32. O’Brien FJ. Biomaterials & scaffolds for tissue engineering. Mater Today. 2011;14:88-95.
33. Ahmed EM. Hydrogel: Preparation, characterization, and applications: A review. J Adv Res. 2015;6:105-121.
34. Wu W qiang, Peng S, Song Z yuan, Lin S. Collagen biomaterial for the treatment of myocardial infarction: an update on cardiac tissue engineering and myocardial regeneration. Drug Deliv Transl Res. 2019;9:920-934.
35. Blackburn NJR, Sofrenovic T, Kuraitis D, Ahmadi A, McNeill B, Deng C, Rayner KJ, Zhong Z, Ruel M, Suuronen EJ. Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction. Biomaterials. 2015;39:182-192.
36. Venugopal JR, Prabhakaran MP, Mukherjee S, Ravichandran R, Dan K, Ramakrishna S. Biomaterial strategies for alleviation of myocardial infarction. J R Soc Interface. 2012;9:1-19.
37. Chiu LLY, Radisic M. Cardiac tissue engineering. Curr Opin Chem Eng. 2013;2:41-52.
38. Jackman CP, Shadrin IY, Carlson AL, Bursac N. Human Cardiac Tissue Engineering: From Pluripotent Stem Cells to Heart Repair. Curr Opin Chem Eng. 2015;7:57-64.
39. Lee KY, Mooney DJ. Hydrogels for tissue engineering. Chem Rev. 2001;101:1869-1879.
40. Wassenaar JW, Braden RL, Osborn KG, Christman KL. Modulating in vivo degradation rate of injectable extracellular matrix hydrogels. J Mater Chem B. 2016;4:2794-2802.
41. Efraim Y, Sarig H, Cohen Anavy N, Sarig U, de Berardinis E, Chaw S-Y, Krishnamoorthi M, Kalifa J, Bogireddi H, Duc TV, Kofidis T, Baruch L, Boey FYC, Venkatraman SS, Machluf M. Biohybrid cardiac ECM-based hydrogels improve long term cardiac function post myocardial infarction. Acta Biomater. 2017;50:220-233.
42. Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marbán L, Mendizabal A, Johnston P V, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marbán E. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet (London, England). 2012;379:895-904.
43. Marbán E, Cingolani E. Heart to heart: cardiospheres for myocardial regeneration. Hear Rhythm. 2012;9:1727-1731.
44. Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, et al. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature. 2015;525:479-485.
45. Suzuki G, Weil BR, Leiker MM, Ribbeck AE, Young RF, Cimato TR, Canty Jr JM. Global Intracoronary Infusion of Allogeneic Cardiosphere-Derived Cells Improves Ventricular Function and Stimulates Endogenous Myocyte Regeneration throughout the Heart in Swine with Hibernating Myocardium. PLoS One. 2014;9:e113009.
46. Martin K, Huang C-L, Caplice NM. Regenerative approaches to post-myocardial infarction heart failure. Curr Pharm Des. 2014;20:1930-1940.
47. Gallet R, Tseliou E, Dawkins J, Middleton R, Valle J, Angert D, Reich H, Luthringer D, Kreke M, Smith R, Marbán L, Marbán E. Intracoronary delivery of self-assembling heart-derived microtissues (cardiospheres) for prevention of adverse remodeling in a pig model of convalescent myocardial infarction. Circ Cardiovasc Interv. 2015;8.
48. Ng HW, Zhang Y, Naffa R, Prabakar S. Monitoring the degradation of collagen hydrogels by collagenase clostridium histolyticum. Gels. 2020;6.
49. Dib N, Khawaja H, Varner S, McCarthy M, Campbell A. Cell therapy for cardiovascular disease: A comparison of methods of delivery. J Cardiovasc Transl Res. 2011;4.
50. Sanz-Ruiz R, Plasencia AC, Borlado LR, Fernández-Santos ME, Al-Daccak R, Claus P, Palacios I, Sádaba R, Charron D, Bogaert J, Mulet M, Yotti R, Gilaberte I, Bernad A, Bermejo J, Janssens S, Fernández-Avilés F. Rationale and Design of a Clinical Trial to Evaluate the Safety and Efficacy of Intracoronary Infusion of Allogeneic Human Cardiac Stem Cells in Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction: The Randomized Multicenter Double-Blind Controlled CAREMI Trial (Cardiac Stem Cells in Patients with Acute Myocardial Infarction). Circ Res. 2017;121.
51. Chugh AR, Beache GM, Loughran JH, Mewton N, Elmore JB, Kajstura J, Pappas P, Tatooles A, Stoddard MF, Lima JAC, Slaughter MS, Anversa P, Bolli R. Administration of cardiac stem cells in patients with ischemic cardiomyopathy: The SCIPIO trial: Surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation. 2012;126.
52. Ostovaneh MR, Makkar RR, Ambale-Venkatesh B, Ascheim D, Chakravarty T, Henry TD, Kowalchuk G, Aguirre F V., Kereiakes DJ, Povsic TJ, Schatz R, Traverse JH, Pogoda J, Smith RD, Marbán L, Marbán E, Lima JAC. Effect of cardiosphere-derived cells on segmental myocardial function after myocardial infarction: ALLSTAR randomised clinical trial. Open Hear. 2021;8.
Published
2025-07-29
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How to Cite
Evananda, M., Salim, A., Surya, S., & Suastika, L. O. (2025). Collagen-Based Hydrogel Encapsulated Cardiosphere-Derived Cell (CDC): Potential of Stem Cells as Tissue Repair Therapy Post-Acute Myocardial Infarction. Indonesian Journal of Cardiology, 45(4). https://doi.org/10.30701/ijc.1281
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Review Article
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