Correlation between NT-proBNP plasma levels with mitral annular Tissue Doppler Velocities in Heart Failure patients
Abstract
Background.N-terminal pro brain natriuretic peptide (NT-proBNP) will release from myocite granules in a condition of increased cardiac wall-stress in heart failure (HF) patients, and its plasma level elevation had been widely used as a parameter of diagnosis, functional class, treatment monitoring and prognostication. Pulsed-wave tissue Doppler velocities of mitral annulus (Tissue Doppler Imaging/TDI) currently known had an ability to detect move-ment changes of cardiac wall in HF patients. But only few research to see the correlation between them, with various selection of patients and results.Aim. To determine whether plasma NT-proBNP levels correlate with mitral annulus velocities measured by TDI and to search which component had the strongest correlation.
Methods.One hundred consecutive patients with HF who came for echocardiography examination in The National Cardiac Center Harapan Kita Jakarta underwent an additional TDI procedure (Sm, Emand E/Em component). Before or after echocardiography, venous blood sample was collected for plasma NT-proBNP examination. We determined the cor-relation between plasma NT-proBNP level and TDI results, and assessed which component had the strongest correlation.
Results.There were 74 men and 26 women of HF patients with mean of age 54 y.o. Functional NYHA Class II were 28 patients, NYHA Class III 42 patients and NYHA Class IV 30 patients. The causes of HF were CAD 49 patients, HHD 19 patients, Valve Disease 23 patients, DCM 8 patients and other 1 patient. There were 64 patients with sinus rhythm and 36 patients with atrial fibrillation. There were 17 diastolic HF patients and 83 systolic HF patients. Fifty patients with significant MR and 50 patients without significant MR. We found the strongest significant negative correlation (r= -0,713, p0,000) between plasma NT-proBNP level and Emcomponent. Smalso had a significant negative correlation, but Emhad a stronger correlation than Sm. E/Emcomponent had a weak significant positive correlation.
Conclusion.Elevated plasma NT-proBNP levels correlates strongly with declining velocities of TDI early diastolic Emcomponent in HF patients.
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References
Carolyn Y, Solomon SD. A Clinician’s Guide to Tissue Doppler Imaging. Circulation. 2006;113:e396-e398.
Hall C. Essential biochemistry and physiology of (NT-pro)BNP. Eur J Heart Fail. 2004;6:257-260.
Cowie MR, Jourdain P, Maisel A, et al. Clinial applications of B-type natriuretic peptide (BNP) testing. Eur Heart J. 2003;24:1710-1718.
Masson S, Vago T, Baldi G, et al. Comparative measurement of N-terminal pro-brain natriuretic peptide and brain natriuretic peptide in ambulatory patients with heart failure. Clin Chem Lab Med. 2002;40:761-763.
Pfister R, Scholz M, Wielcknes K, Erdmann E, Schneider CA. Use of NT-proBNP in routine testing and comparison to BNP. Eur J Heart Fail. 2004;6:289-293.
Mueller T, Gegenhuber A, Poelz W, ?altmayer M. ?ead-to-head comparison of the diagnostic utility of BNP and NT-proBNP in symptomatic and asymptomatic structural heart disease. Clin Chim Acta.2004;341:41-48.
Seino Y, Ogawa A, Yamashita T, et al. Application of NT-proB- Application of NT-proB-NP and BNP measurements in cardiac care: a more discerning marker for the detection and evaluation of heart failure. Eur J Heart Fail. 2004;6:295-300.
Tretjak M, Verovnik F, Benko D, Kozelj M. Tissue Doppler velocities of mitral annulus and NT-proBNP in patients with heart failure. Eur J Heart Fail. 2005;7:520-524.
Mottram PM, Leano R, Marwick T?. Usefulness of B-type natriuretic peptide in hypertensive patients with exertional dyspnea and normal left ventricular ejection fraction and cor-relation with new echocardiographic indexes of systolic and diastolic function. Am J Cardiol. 2003;92:1434-1438.
Troughton RW, Prior DL, Pereira JJ, Martin M, Fogarty A, Morehead A, et al. Plasma B-type natriuretic peptide levels in systolic heart failure. J Am Coll Cardiol. 2004;43:416-422.
Alam M, Wardell J, Andersson E, Nordlander R, Samad B. Assessment of left ventricular function using mitral annular velocities in patients with congestive heart failure with or with-out the presence of significant mitral regurgitation. J Am Soc Echocardiogr. 2003;16:240-245.
Sohn DW, Song JM, Zo J?, et al. Mitral annulus velocity in the evaluation of left ventricular diastolic function in atrial fibrillation. J Am Soc Echocardiogr.1992;12:927-931.
Hall C. Essential biochemistry and physiology of (NT-pro)BNP. Eur J Heart Fail. 2004;6:257-260.
Cowie MR, Jourdain P, Maisel A, et al. Clinial applications of B-type natriuretic peptide (BNP) testing. Eur Heart J. 2003;24:1710-1718.
Masson S, Vago T, Baldi G, et al. Comparative measurement of N-terminal pro-brain natriuretic peptide and brain natriuretic peptide in ambulatory patients with heart failure. Clin Chem Lab Med. 2002;40:761-763.
Pfister R, Scholz M, Wielcknes K, Erdmann E, Schneider CA. Use of NT-proBNP in routine testing and comparison to BNP. Eur J Heart Fail. 2004;6:289-293.
Mueller T, Gegenhuber A, Poelz W, ?altmayer M. ?ead-to-head comparison of the diagnostic utility of BNP and NT-proBNP in symptomatic and asymptomatic structural heart disease. Clin Chim Acta.2004;341:41-48.
Seino Y, Ogawa A, Yamashita T, et al. Application of NT-proB- Application of NT-proB-NP and BNP measurements in cardiac care: a more discerning marker for the detection and evaluation of heart failure. Eur J Heart Fail. 2004;6:295-300.
Tretjak M, Verovnik F, Benko D, Kozelj M. Tissue Doppler velocities of mitral annulus and NT-proBNP in patients with heart failure. Eur J Heart Fail. 2005;7:520-524.
Mottram PM, Leano R, Marwick T?. Usefulness of B-type natriuretic peptide in hypertensive patients with exertional dyspnea and normal left ventricular ejection fraction and cor-relation with new echocardiographic indexes of systolic and diastolic function. Am J Cardiol. 2003;92:1434-1438.
Troughton RW, Prior DL, Pereira JJ, Martin M, Fogarty A, Morehead A, et al. Plasma B-type natriuretic peptide levels in systolic heart failure. J Am Coll Cardiol. 2004;43:416-422.
Alam M, Wardell J, Andersson E, Nordlander R, Samad B. Assessment of left ventricular function using mitral annular velocities in patients with congestive heart failure with or with-out the presence of significant mitral regurgitation. J Am Soc Echocardiogr. 2003;16:240-245.
Sohn DW, Song JM, Zo J?, et al. Mitral annulus velocity in the evaluation of left ventricular diastolic function in atrial fibrillation. J Am Soc Echocardiogr.1992;12:927-931.
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How to Cite
Siregar, R. A., Kalim, H., Siswanto, B., & Soesanto, A. (1). Correlation between NT-proBNP plasma levels with mitral annular Tissue Doppler Velocities in Heart Failure patients. Indonesian Journal of Cardiology, 31(3), 168-74. https://doi.org/10.30701/ijc.v31i3.129
Section
Clinical Research
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