Pemeriksaan BNP atau NT pro BNP pada Pasien Gagal Jantung
Abstract
Beberapa permasalahan masih sering dihadapi berkaitan dengan diagnosis, evaluasi keberhasilan terapi, penekanan angka morbiditas dan mortalitas gagal jantung. Seperti misalnya, pada kondisi gawat darurat yang membutuhkan diagnosis dan terapi cepat dan akurat, kadang sulit untuk membedakan sesak nafas akibat gagal jantung atau akibat penyakit lain seperti penyakit paru dan metabolik. Hingga saat inipun pemulangan pasien dari perawatan rumah sakit sebagian besar didasarkan atas berkurangnya atau hilangnya keluhan, meskipun mungkin belum dilakukan titrasi terapi yang optimal. Hal itu menyebabkan tingginya angka kematian dan rawat ulang pasien gagal jantung. Lebih jauh, hingga saat ini belum ada metoda yang rutin dipakai untuk meng-evaluasi efek dari terapi yang telah diberikan pada level molekuler.Oleh karena itu, perlu ada alat diagnostik untuk mengetahui fungsi jantung secara cepat dan tepat, yang dapat membedakan sesak karena gagal jantung atau faktor lain, dan dapat pula menjadi predikor prognosis pasien gagal jantung.
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References
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McCullough PA, Omland T, Maisel AS, B-Type Natriuretic Peptides: a diagnostic breakthrough for Clinicians. Rev in cardiovasc med. 2003; 4: 72-80.
Stein BC, Levin RI. Natriuretic peptides: physiology, therapeutic potential, and risk stratification in ischemic heart disease. Am Heart J 1998;135:914-923.
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Wei CM, Heublein DM, Perrella MA, et al. Natriuretic peptide system in human heart failure. Circulation 1993; 88: 1004-1009.
Richards AM, Nicholls MG, Yandle TG et al. Plasma N-terminal probrain natriuretic peptide and adrenomedullin: new neurohormonal predictors of left ventricular function and prognosis after myocardial infarction. Circulation 1998; 97:1921–1929.
Utility of B-type natriuretic peptide (BNP) in the diagnosis of CHF in an urgent care setting. J Am Coll Cardiol. 2001;37:379–385.
Davis M, Espiner E, Richards G, et al. Plasma brain natriuretic peptide in assessment of acute dyspnea. Lancet 1994;343:440-444.
McDonagh TA, Robb SD, Murdoch DR, et al. Biochemical detection of left-ventricular systolic dysfunction. Lancet. 1998;351:9–13.
Vasan RS, Benjamin EJ, Larson MG, et al. Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study. JAMA. 2002;288:1252–1259.
Koglin J, Pehlivanli S, Schwaiblmair M, et al. Role of brain natriuretic peptide in risk stratification of patients with congestive heart failure. J Am Coll Cardiol 2001;38:1934–1941.
Troughton RW, Frampton CM, Yandle TG, et al. Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. Lancet. 2000;355:1126 –1130.
Mueller C, Scholer A, Laule-Kilian K, et al. Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea. N Engl J Med 2004;350:647- 654.
Krishnaswamy P, Lubien E, Clopton P, et al. Utility of B-natriuretic peptide levels in identifying patients with left ventricular systolic or diastolic dysfunction. Am J Med 2001;111:274-279
Dokainish H, Zoghbi WA, Lakkis NM, et al. Optimal Noninvasive Assessment of Left Ventricular Filling Pressures A Comparison of Tissue Doppler Echocardiography and B-Type Natriuretic Peptide in Patients With Pulmonary Artery Catheters. Circulation. 2004;109:2432-2439.
Cheng VL, Kazanagra R, Garcia A, et al. A rapid bedside test for B-type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study. J Am Coll Cardiol 2001;37:386-391.
Redfield MM, Rodeheffer RJ, Jacobsen SJ, et al. Plasma brain natriuretic peptide concentration: impact of age and gender. J Am Coll Cardiol. 2002;40:976–982.
Wang TJ, Larson MG, Levy D, et al. Impact of Obesity on Plasma Natriuretic Peptide Levels. Circulation. 2004; 109:594-600.
Vickery S, Christopher P. Price CP, John RI, et al. B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP in Patients With CKD: Relationship to Renal Function and Left Ventricular Hypertrophy. Am J Kidney Dis. 2005; 46: 610-620.
McCullough PA, Omland T, Maisel AS, B-Type Natriuretic Peptides: a diagnostic breakthrough for Clinicians. Rev in cardiovasc med. 2003; 4: 72-80.
Stein BC, Levin RI. Natriuretic peptides: physiology, therapeutic potential, and risk stratification in ischemic heart disease. Am Heart J 1998;135:914-923.
Nakao K, Ogawa Y, Suga S et al. Molecular biology and biochemistry of the natriuretic peptide system. I: Natriuretic peptides. J Hypertens 1992; 10: 907-912.
Wei CM, Heublein DM, Perrella MA, et al. Natriuretic peptide system in human heart failure. Circulation 1993; 88: 1004-1009.
Richards AM, Nicholls MG, Yandle TG et al. Plasma N-terminal probrain natriuretic peptide and adrenomedullin: new neurohormonal predictors of left ventricular function and prognosis after myocardial infarction. Circulation 1998; 97:1921–1929.
Utility of B-type natriuretic peptide (BNP) in the diagnosis of CHF in an urgent care setting. J Am Coll Cardiol. 2001;37:379–385.
Davis M, Espiner E, Richards G, et al. Plasma brain natriuretic peptide in assessment of acute dyspnea. Lancet 1994;343:440-444.
McDonagh TA, Robb SD, Murdoch DR, et al. Biochemical detection of left-ventricular systolic dysfunction. Lancet. 1998;351:9–13.
Vasan RS, Benjamin EJ, Larson MG, et al. Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study. JAMA. 2002;288:1252–1259.
Koglin J, Pehlivanli S, Schwaiblmair M, et al. Role of brain natriuretic peptide in risk stratification of patients with congestive heart failure. J Am Coll Cardiol 2001;38:1934–1941.
Troughton RW, Frampton CM, Yandle TG, et al. Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. Lancet. 2000;355:1126 –1130.
Mueller C, Scholer A, Laule-Kilian K, et al. Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea. N Engl J Med 2004;350:647- 654.
Krishnaswamy P, Lubien E, Clopton P, et al. Utility of B-natriuretic peptide levels in identifying patients with left ventricular systolic or diastolic dysfunction. Am J Med 2001;111:274-279
Dokainish H, Zoghbi WA, Lakkis NM, et al. Optimal Noninvasive Assessment of Left Ventricular Filling Pressures A Comparison of Tissue Doppler Echocardiography and B-Type Natriuretic Peptide in Patients With Pulmonary Artery Catheters. Circulation. 2004;109:2432-2439.
Cheng VL, Kazanagra R, Garcia A, et al. A rapid bedside test for B-type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study. J Am Coll Cardiol 2001;37:386-391.
Redfield MM, Rodeheffer RJ, Jacobsen SJ, et al. Plasma brain natriuretic peptide concentration: impact of age and gender. J Am Coll Cardiol. 2002;40:976–982.
Wang TJ, Larson MG, Levy D, et al. Impact of Obesity on Plasma Natriuretic Peptide Levels. Circulation. 2004; 109:594-600.
Vickery S, Christopher P. Price CP, John RI, et al. B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP in Patients With CKD: Relationship to Renal Function and Left Ventricular Hypertrophy. Am J Kidney Dis. 2005; 46: 610-620.
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How to Cite
Hersunarti, N., & Rohman, M. (1). Pemeriksaan BNP atau NT pro BNP pada Pasien Gagal Jantung. Indonesian Journal of Cardiology, 28(3), 229-232. https://doi.org/10.30701/ijc.v28i3.247
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