Early Experience of MitraClip Procedure at National Cardiovascular Center Harapan Kita, Jakarta


Background: Percutaneous mitral valve repair (PMVR) with MitraClip is considered as an optional treatment for patients with significant MR who are high risk for having surgery. This novel therapy is less invasive, safe, and effective for MR reduction, and hence improve symptoms of heart failure, as well as reverse left ventricle remodeling. The purpose of this study was to report the early experience of Mitraclip procedure for treating significant MR at the National Cardiovascular Center Harapan Kita.
Methods: This retrospective study was conducted at National Cardiovascular Center Harapan Kita Hospital, Jakarta. The data was retrieved from computerized database and medical records from February 2014 to January 2015, and then analyzed with SPSS.
Results: A total of 6 patients with age 51 - 75 years old, underwent MitraClip procedure. Of all patients, the MR were severe in 5 patients and moderate in 1 patient. One was female and 5 were male. Among these patients, 2 were degenerative MR and 6 were functional MR. Two patients were treated with single MitraClip and 4 patients required double MitraClip. Post proccedure, there was reduction of MR to mild was achieved in 2 patients and to moderate in 4 patients. The left ventricular end diastolic dimension decreased from 66 ± 6.5 mm at baseline to 59 ± 7.3 mm (p=0.04) and end systolic dimensions decreased from 50 ± 10.6 mm at baseline to 48 ± 10.0 mm before discharge (p=0.27) as evaluated from predischarge echocardiography. At one month after procedure, 2 patients were in New York Heart Association (NYHA) functional class I and 4 patients were in class II. In-hospital mortality was 0%. Only 1 patient was re-hospitalized after procedure due to heart failure.
Conclusion: From our early experience, MitraClip was considered an effective and safe option for patients with functional and degenerative MR who are at high risk for open-heart surgery. Left ventricle dimension, NYHA functional class, MR reduction, and re-hospitalization rate were improved after procedure.


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1. Iung B, Baron G, Tornos P, et al. Valvular heart disease in the community: a European experience. Curr Probl Cardiol 2007;32:609-61.

2. Yun KL, Miller DC. Mitral valve repair versus replacement. Cardiol Clin 1991;9:315-27.

3. Olson LJ, Subramanian R, Ackermann DM, et al. Surgical pathology of the mitral valve: a study of 712 cases spanning 21 years. Mayo Clin Proc 1987;62:22-34.

4. Taramasso M, Buzzatti N, La Canna G, et al. Interventional vs. surgical mitral valve therapy. Herz 2013;38:460-6.

5. Carabello BA. The current therapy for mitral regurgitation. J Am Coll Cardiol 2008;52:319-26.

6. Alfieri O, Maisano F, De Bonis M, et al. The double-orifice technique in mitral valve repair: a simple solution for complex problems. J Thorac Cardiovasc Surg 2001;122:674-81.

7. Feldman T, Kar S, Rinaldi M, et al. Percutaneous mitral repair with the MitraClip system: safety and midterm durability in the initial Everest (Endovascular Valve Edge-to-Edge REpair Study) cohort. J Am Coll Cardiol 2009;54:686-94.

8. Tamburino C, Ussia GP, Maisano F, Capodanno D, La Canna G, Scandura S, et al. Percutaneous mitral valve repair with the MitraClip system acute result from a real world setting. Eur Heart J 2010;31(11):1382-9.

9. Franzen O, van der Heyden J, Baldus S, et al. MitraClip® therapy in patients with end-stage systolic heart failure. Eur J Heart Fail 2011;13:569-576.

10. Baldus S, Schilinger W, Franzen O, Bekerdian R, Sievert H, Schofer J, et al. MitraClip therapy in daily cilinical practice: initial results from the German transcatheter mitral valve interventions (TRAMI) registry. Eur J Heart Fail 2012;14(9) 1050-5.

11. Whitlow PL, Feldman T, Pedersen WR, et al. Acute and 12-month results with catheter-based mitral valve leaflet repair: the EVEREST II (Endovascular Valve Edge-to-Edge Repair) High Risk Study. J Am Coll Cardiol 2012;59:130-139.

12. Rudolph V, Knap M, Franzen O, et al. Echocardiographic and clinical outcomes of MitraClip therapy in patients not amenable to surgery. J Am Coll Cardiol 2011;58:2190-2195.

13. Fabio G, Baldassare F, Rubia B, Pietro B, et al. Noninvasive evaluation of cardiomechanics in patients undergoing MitraClip procedure. Cardiovasc Ultrasound 2013;11:13

14. Imasaka KI, Tomita Y, Tanoue Y, Tominaga R, Tayama E, Onitsuka H, et al. Early mitral valve surgery for chronic severe mitral regurgitation optimizes left ventricular performance and left ventricular mass regression. J Thorac Cariovasc Surg 2012.

15. Hung L, Rahimtoola SH. Reverse remodeling after heart valve replacement and repair. IN: Greeberg B, editor. Cardioac remodeling mechanism and treatment, New York: Taylor & Francis; 2006.p.417-40.
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Early Experience of MitraClip Procedure at National Cardiovascular Center Harapan Kita, Jakarta. (2016). Indonesian Journal of Cardiology, 36(2), 82-7. https://doi.org/10.30701/ijc.v36i2.462
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