Blood Pressure Reduction By Rosela ( Hisbiscus Sabdariffa) in Elderly Women: Role of Vasodilation Response of Nitric Oxide
Abstract
Background. Herbal medication for hypertension is common in population. This study aims to seek the role of nitric oxide (NO) in the mechanism of blood pressure reduction after administration of rosella tea (hisbiscus sabdariffa).Methods. A pre-post study was conducted in elderly hypertensive women at UPTD Rumoh Sejahtera Banda Aceh. Subjects were given 2 grams rosella tea after meal twice a day for 3 weeks. Sistolic and diastolic blood pressure, and NO concentration were compare pre and post rosella administration between control and experiment groups.
Results. Rosela group has lower systolic and diastolic pressure as compare to control group (140,00 ± 10,00 vs 142,85 ± 4.87 mmHg; 84,28 ± 5,34 vs 89,28 ± 4,87mmHg, p < 0.05 respectively). Systolic pressure reduction by rosella was 14,77% with average pressure reduction of 24,28 mmHg. Diastolic pressure reduction was 9,22% with averagepressure reduction of 8,57 mmHg. No significant difference of nitric oxide concentration between groups (4,85 ± 2,16 vs 4,55 ± 3,11 µM, p>0.05).
Conclusion. Rosella reduce systolic and diastolic blood pressure of elderly hypertensive women with mechanism out of nitric oxide level.
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References
Biro Pusat Statistik. 2000. Sensus Penduduk Indonesia. Jakarta.
Departemen Kesehatan Republik Indonesia. Menyongsong Lanjut Usia Tetap Sehat dan Berguna, Menyokong Penuh Penanggulangan Hipertensi. Melalui
Frohlich, E.D. 1999. Risk Mechanism in Hypertensive Heart Disease. Hypertension 34; 782-789.
James, M.A. Tullett, J. Hemsley, A.G. & Shore, A.C. 2006. Effects of Aging and Hypertension on the Microcirculation. The American Heart Assosiation. Hypertension 47:109-114.
National Academy on An Aging Society, USA. June 2005. Hypertension: A Common Condition for Older Americans. Australian Family Physician. 34(6):412-424.
Panza, J.A. 2001. High-Normal Blood Pressure More Than High than Normal. N Engl J Med. 1345:18-23.
Rasansky, J.H. 2007. Hypertension and Aging. Journal of Human Hypertension 21: 96-98.
Reckelhoff, J.F & Fortepiani, L.A. 2004. Novel Mechanism Responsible for Postmenopausal Hypertension. Hypertension 43: 918-923.
Alberts. 2002. Molecular Biology.New York: W.H. Freeman and Company.
Barton, M. Cosentio, F. Brandes, R.P. Moreau, P. Shaw, S. Luscher, T.F. 1997. Anatomic Heterogeneity of Vascular Aging. J Am Coll Cardiol29 (Suppl A): 304A-310A.
Boulanger. Chantal, M. & Vanhoutte, P.M. 1994. The Endothelium: Apivotal Role in Health and Cardiovascular Disease. Houston : Monograph.
Luscher, T.F & Barton, M. 1997. Biology of Endothelium. Clin. Cardiol. 20:113-1110.
Herrera-Arellanoa, A, Flores-Romerob, S, Chavez-Sotoc, M.A, TortorielloaJ. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine 11 (2004) 375–382.
Safar, M.E. & Laurent, P. 2003. Pulse Pressure andarterial Stiffness in Rats: Comparison with Humans. Am J Physiol Heart Circ Physiol. 285: H1363-H1369.
Stamler, J.S. & Meissner G. 2001. Physiology of Nitric Oxide in Skeletal Muscle. Physiological Reviews 81(1):209-237.
Taddei, S. Virdis, A. Mattei, P. Ghiadoni, L. Fasalo, C.B. Sudano, I. & Salvetti A. 1997. Hypertension Causes Premature Aging of Endothelial Function in Humans. American Heart Association, Inc. Hypertension 29: 736-743.
Ungvary, Z. & Koller, A. 2000. Endothelin and Prostaglandin H2/Thromboxane A2 Enhance Myogenic Constriction in Hypertension by Increasing Ca2+ Sensitivity of Arteriolar Smooth Muscle. American Heart Association, Inc. Hypertension 36: 856-872.
Woodman, C.R. Price, E.M & Laughlin, M.H. 2003. Aging Impairs Nitric Oxide and Prostacyclin Mediation of Endothelium-Dependent Dilation in Soleus Feed Arteries. The American Physiological Society 95: 2164-2170.
Wright, P. 1995. Nitric Oxide: From Menace to Marvel of the Decade. The Royal Society and Association of British Science Writers.
Mozaffari-Khosravi, H, Jalali-Khanabadi ,BA, Afkhami-Ardekani M, Fatehi ,F and M Noori-Shadkam. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. Journal of Human Hypertension (2009) 23, 48–54
Presiden Republik Indonesia. UU 13/1998. Kesejahteraan Lanjut Usia. Tanggal: 30 November 1998: Jakarta.
Haji-Faraji, M., Haji-Tarkhani, A., 1999. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. Journal of Ethnopharmacology 65, 231–236.
Adegunloye, B.J., Omoniyi, J.O., Owolabi, O.A., Ajagbona, O.P., Sofola, O.A., Coker, H.A., 1996. Mechanisms of blood pressure lowering effects of the calyx extract of Hibiscus sabdariffa in rats. African Journal of Medicine and Medical Sciences 25, 235–238.
Herrera-Arellano, A., Flores-Romero, S., Chavez-Soto, M.A., Tortoriello, J., 2004. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine 11, 375–382.
Hirunpanich, V., Utaipat, A., Morales, N.P., Bunyapraphatsara, N., Sato, H., Herunsalee, A., Suthisisang, C., 2005. Antioxidant effects of aqueous extracts from dried calyx of Hibiscus sabdariffa LINN. (Roselle) in vitro using rat low-density lipoprotein (LDL). Biological and Pharmaceutical Bulletin 28, 481–484.
Departemen Kesehatan Republik Indonesia. Menyongsong Lanjut Usia Tetap Sehat dan Berguna, Menyokong Penuh Penanggulangan Hipertensi. Melalui
Frohlich, E.D. 1999. Risk Mechanism in Hypertensive Heart Disease. Hypertension 34; 782-789.
James, M.A. Tullett, J. Hemsley, A.G. & Shore, A.C. 2006. Effects of Aging and Hypertension on the Microcirculation. The American Heart Assosiation. Hypertension 47:109-114.
National Academy on An Aging Society, USA. June 2005. Hypertension: A Common Condition for Older Americans. Australian Family Physician. 34(6):412-424.
Panza, J.A. 2001. High-Normal Blood Pressure More Than High than Normal. N Engl J Med. 1345:18-23.
Rasansky, J.H. 2007. Hypertension and Aging. Journal of Human Hypertension 21: 96-98.
Reckelhoff, J.F & Fortepiani, L.A. 2004. Novel Mechanism Responsible for Postmenopausal Hypertension. Hypertension 43: 918-923.
Alberts. 2002. Molecular Biology.New York: W.H. Freeman and Company.
Barton, M. Cosentio, F. Brandes, R.P. Moreau, P. Shaw, S. Luscher, T.F. 1997. Anatomic Heterogeneity of Vascular Aging. J Am Coll Cardiol29 (Suppl A): 304A-310A.
Boulanger. Chantal, M. & Vanhoutte, P.M. 1994. The Endothelium: Apivotal Role in Health and Cardiovascular Disease. Houston : Monograph.
Luscher, T.F & Barton, M. 1997. Biology of Endothelium. Clin. Cardiol. 20:113-1110.
Herrera-Arellanoa, A, Flores-Romerob, S, Chavez-Sotoc, M.A, TortorielloaJ. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine 11 (2004) 375–382.
Safar, M.E. & Laurent, P. 2003. Pulse Pressure andarterial Stiffness in Rats: Comparison with Humans. Am J Physiol Heart Circ Physiol. 285: H1363-H1369.
Stamler, J.S. & Meissner G. 2001. Physiology of Nitric Oxide in Skeletal Muscle. Physiological Reviews 81(1):209-237.
Taddei, S. Virdis, A. Mattei, P. Ghiadoni, L. Fasalo, C.B. Sudano, I. & Salvetti A. 1997. Hypertension Causes Premature Aging of Endothelial Function in Humans. American Heart Association, Inc. Hypertension 29: 736-743.
Ungvary, Z. & Koller, A. 2000. Endothelin and Prostaglandin H2/Thromboxane A2 Enhance Myogenic Constriction in Hypertension by Increasing Ca2+ Sensitivity of Arteriolar Smooth Muscle. American Heart Association, Inc. Hypertension 36: 856-872.
Woodman, C.R. Price, E.M & Laughlin, M.H. 2003. Aging Impairs Nitric Oxide and Prostacyclin Mediation of Endothelium-Dependent Dilation in Soleus Feed Arteries. The American Physiological Society 95: 2164-2170.
Wright, P. 1995. Nitric Oxide: From Menace to Marvel of the Decade. The Royal Society and Association of British Science Writers.
Mozaffari-Khosravi, H, Jalali-Khanabadi ,BA, Afkhami-Ardekani M, Fatehi ,F and M Noori-Shadkam. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. Journal of Human Hypertension (2009) 23, 48–54
Presiden Republik Indonesia. UU 13/1998. Kesejahteraan Lanjut Usia. Tanggal: 30 November 1998: Jakarta.
Haji-Faraji, M., Haji-Tarkhani, A., 1999. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. Journal of Ethnopharmacology 65, 231–236.
Adegunloye, B.J., Omoniyi, J.O., Owolabi, O.A., Ajagbona, O.P., Sofola, O.A., Coker, H.A., 1996. Mechanisms of blood pressure lowering effects of the calyx extract of Hibiscus sabdariffa in rats. African Journal of Medicine and Medical Sciences 25, 235–238.
Herrera-Arellano, A., Flores-Romero, S., Chavez-Soto, M.A., Tortoriello, J., 2004. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine 11, 375–382.
Hirunpanich, V., Utaipat, A., Morales, N.P., Bunyapraphatsara, N., Sato, H., Herunsalee, A., Suthisisang, C., 2005. Antioxidant effects of aqueous extracts from dried calyx of Hibiscus sabdariffa LINN. (Roselle) in vitro using rat low-density lipoprotein (LDL). Biological and Pharmaceutical Bulletin 28, 481–484.
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How to Cite
Yusni, I., & Syahrul, M. (1). Blood Pressure Reduction By Rosela ( Hisbiscus Sabdariffa) in Elderly Women: Role of Vasodilation Response of Nitric Oxide. Indonesian Journal of Cardiology, 33(3), 137-45. https://doi.org/10.30701/ijc.v33i3.38
Section
Clinical Research
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