Dyslipidemia Aterogenic, antara fakta dan harapan yang akan datang
Abstract
Disregulasi dari metabolisme lipoprotein merupakan inti dari perkembangan aterosklerosis. Suatu studi epidemi prospektif secara konsisten menunjukkan bahwa kenaikan dari Low Density Lipoprotein Cholesterol (LDL-C) dihubungkan dengan peningkatan risiko dari penyakit kardiovaskular, namun hal tersebut mungkin secara terpisah menyebabkan dislipidemia aterogenik, jika bergabung dengan hipertensi, obesitas sentral dan resistensi insulin, yang secara bersamaan dikenal sebagai sindroma metabolik. Dislipidemia aterogenik ditandai dengan tingginya trigliserid (TG) plasma, rendahnya High Density Lipoprotein Cholesterol (HDL-C) dan tingginya konsentrasi apolipoprotein (apo)-B yang berisi lipoprotein, khususnya peningkatan small dense LDL.Hipertrigliserid (HTG) adalah peningkatan kadar trigliserid (TG) puasa di atas normal (> 150 mg/dl). Pada 2010 di Amerika Serikat ada 74,6 juta penduduk mempunyai peningkatan kadar trigliserid, 36,4 juta diantara mereka memiliki kadar triglsierid yang tinggi (200-499 mg/dl), dengan meningkatnya prevalensi ini secara paralel juga terjadi peningkatan yang tajam terhadap kejadian obesitas.1
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References
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Balakumar P. Babbar L, Kalra S, Mahadevan N, Sritharan S, Krishan P. Is hypertriglyceridemia a key detrimental factor or associative triggering factor for cardiovascular abnormalities? Syst Rev Pharm 2012; 3:1-3.
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Watts GF, Karpe F. Why, when and how should hypertriglyceridemia be treated in the high risk cardiovascular patient? Expert Rev Cardiovasc Ther 2011; 9:987-997.
Tenenbaum A, Klempfner R, Fisman EZ. Hypertriglyceridemia: A too long unfairly neglected major cardiovascular risk factor. Cardiovasc Diabetol 2014; 13: 159-168
Maki KC, Bays HE, Dicklin MR. Treatment options for the management of hypertriglyceridemia: Strategies based on the best available evidence. J Clin Lipidol 2012; 6:413-426.
Balakumar P. Babbar L, Kalra S, Mahadevan N, Sritharan S, Krishan P. Is hypertriglyceridemia a key detrimental factor or associative triggering factor for cardiovascular abnormalities? Syst Rev Pharm 2012; 3:1-3.
Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet 2014; 384:626-635.
Boren J, Matikainen N, Adiels M, Taskinen MR. Postprandial hypertriglyceridemia as a coronary risk factor. Clinica Chimica Acta 2014; 431:131-142.
Watts GF, Karpe F. Why, when and how should hypertriglyceridemia be treated in the high risk cardiovascular patient? Expert Rev Cardiovasc Ther 2011; 9:987-997.
Tenenbaum A, Klempfner R, Fisman EZ. Hypertriglyceridemia: A too long unfairly neglected major cardiovascular risk factor. Cardiovasc Diabetol 2014; 13: 159-168
Maki KC, Bays HE, Dicklin MR. Treatment options for the management of hypertriglyceridemia: Strategies based on the best available evidence. J Clin Lipidol 2012; 6:413-426.
Published
2016-03-03
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PDF downloads: 3369
How to Cite
Sargowo, D. (2016). Dyslipidemia Aterogenic, antara fakta dan harapan yang akan datang. Indonesian Journal of Cardiology, 36(3), 127-9. https://doi.org/10.30701/ijc.v36i3.474
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