Role of Highly Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease

  • Raymond Pranata Universitas Pelita Harapan
  • Nico Kusuma Universitas Atmajaya
  • Rachel Vania Universitas Pelita Harapan
  • Bambang Budi Siswanto Universitas Indonesia
DOI: https://doi.org/10.30701/ijc.v39i1.794

Abstract

Cardiac troponins (cTn) are the preferred biomarkers of myocardial necrosis, usually used for diagnosis and risk stratification in acute coronary syndromes. Highly sensitive troponin T (hs-cTnT) may be elevated in stable coronary artery disease (SCAD), in which subclinical plaque erosion or rupture and distal embolization and subclinical ischemic episode. hs-cTnT may be used as a prognostic marker in SCAD and can predict cardiovascular events and patient’s mortality rate. In this article, plaque characteristic that is linked to hs-cTnT, it’s used as prognostic biomarker and comparison to other indicators are the focus of discussion.

 

Abstrak

Troponin adalah biomarker yang paling disukai untuk mendeteksi nekrosis miokardium dan untuk mendiagnosis dan stratifikasi risiko pada sindrom koroner akut. Highly sensitive troponin T (hs-cTnT) dapat meningkat pada penyakit jantung koroner stabil dimana terjadi ruptur plak atau erosi dan embolisasi distal sublklinis, dan episode iskemik subklinis. Sehingga biomarker tersebut dapat digunakan sebagai marker prognostik pada penyakit jantung koroner stabil dan dapat memprediksi angka kejadian kardiovaskular dan tingkat mortalitas pasien. Pada artikel ini akan dibahas mengenai karakteristik plak yang dihubungkan dengan peningkatan hs-cTnT, pengunaan sebagai biomarker prognostik dan serta perbandingan dengan indikator lainnya.

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Author Biographies

Raymond Pranata, Universitas Pelita Harapan

Faculty of Medicine, Universitas of Pelita Harapan

Nico Kusuma, Universitas Atmajaya

Faculty of Medicine, Universitas Atmajaya, Jakarta, Indonesia

Rachel Vania, Universitas Pelita Harapan

Faculty of Medicine, Universitas of Pelita Harapan, Banten, Indonesia

Bambang Budi Siswanto, Universitas Indonesia

Faculty of Medicine, Universitas Indonesia, Rumah Sakit Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia

Published
2018-08-21
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How to Cite
Pranata, R., Kusuma, N., Vania, R., & Siswanto, B. (2018). Role of Highly Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease. Indonesian Journal of Cardiology, 39(1), 44-49. https://doi.org/10.30701/ijc.v39i1.794
Issue
Vol 39 No 1 (2018): January - March 2018
Section
Review Article

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