CORELATION OF GLOBAL LONGITUDINAL STRAIN (GLS) – LEFT VENTRICLE AND SOLUBLE SUPRESSION OF TUMORGENICITY 2 (sST2) IN ACUTE HEART FAILURE WITH SYSTOLIC DYSFUNCTION
Abstract
Background : Assessment of left ventricular function in patients with acute heart failure is important for prognostication, determination of treatment plan, for decisions related to expensive device therapies and for assessing response to treatment. Echocardiography is the "gold standard" of assessing left ventricular function, and in establishing a diagnosis of heart failure. Left ventricular Global Longitudinal Strain (GLS) assessed through Speckle Tracking Echocardiography (STE) is currently considered sensitive in assessing left ventricular motion, by analyzing multidimensional myocardial deformation
. s ST2 used to be correlated with stretch miocard and inhibid ligand of IL-33 wich also inhibit the cardioprotectve effect.
Objective : To prove the positive correlation between GLS-left ventricle with soluble ST2.
Methods : This is a correlational study with cosecutive sampling technique. Thirty subjects participate in this reseach and each subject underwent echocardiography and GLS-left ventricle and soluble ST2 blood examination. The correlation between GLS-left ventricle and soluble ST2 were evaluated using Spearman correlation test.
Results : There is a strong, significant, positive correlation between the GLS-left ventricle with soluble ST2 (r = 0.99 and p = 0.0001).
Conclusion : There is a strong, significant, positive correlation between the GLS- left ventricle with soluble ST2.
Keywords : acute heart failure, systolic dysfunction, global longitudinal strain, soluble ST2.
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References
Epidemiology and risk profile of heart failure‘.
Nat Rev Cardiol, 8(1), pp. 30–41.
2. Ponikowski P, Anker S, Habib K, Cowie M, Force T,
et al. 2014. _Heart Failure: Preventing Disease and
Death Worldwide‘. European Society of Cardiology,
pp. 1-39.
3. Motoki H, Borowski A, Shrestha K, Troughton R,
Tang W. et al. 2012. Incremental Prognostic Value
of Assessing Left Ventricular Myocardial Mechanics
in Patients With Chronic Systolic Heart Failure‘. J
Am Coll Cardiol, 60, pp. 2074–81.
4. Nahum J, Bensaid A, Dussault C, Macron L,
Cle´mence D, et al. 2010. _Impact of Longitudinal
Myocardial Deformation on the Prognosis of
Chronic Heart Failure Patients‘. Circ Cardiovasc
Imaging, 3, pp. 249-256.
5. Rangel I, Goncalves A, de Sousaa C, Almeidaa P,
Rodrigues J, et al. 2014. Global longitudinal strain
as a potential prognostic marker in patients with
chronic heart failure and systolic dysfunction‘. Rev
Port Cardiol, 33(7-8), pp. 403-409.
6. Stanton T, Leano R, Marwick T. 2009. _Prediction
of Al -Cause Mortality From Global Longitudinal
Speckle Strain Comparison With Ejection
Fraction and Wall Motion Scoring‘. Circ Cardiovasc
Imaging, 2, pp. 356-364.
7. Mann, D. L., & Chakinala, M. (2015). Heart
Failure: Pathophysiology and Diagnosis. In J. Fauci,
D. Kasper, S. Hauser, D. Longo, L. Jameson, &
Loscalzo, Harrison's principles of Internal Medicine.
New York: Mc Graw Hil.
8. Wettersten, N., & Maisel, A. S. (2016). Biomarkers
for Heart Failure: An Update for Practitioners of
Internal Medicine. The American Journal of Medicine
, 129, 560-567.
9. Van Kimmenade, R. R. & Januzzi, J. L., 2012.
Emerging Biomarkers in Heart Failure. Clinical
Chemistry, 58(1), pp. 127-138.
10. Ciccone, M. M. et al., 2013. A Novel Cardiac Bio-
Marker: ST2: A Review. Molecul.,Volume 18, pp.
15314-15328.
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