PERANAN ACETAMINOPHEN (PARASETAMOL) DALAM PENUTUPAN DUCTUS ARTERIOSUS
Abstract
Abstrak
Patent ductus arteriosus (PDA) adalah kelainan kongenital yang ditandai adanya kegagalan penutupan duktus arteriosus (DA) segera setelah lahir. Dampak tidak menutupnya DA akan terjadi gangguan hemodinamik ,memperberat masalah lain yang menyertai bayi prematur sehingga akan meningkatkan morbiditas dan mortalitas. Parasetamol merupakan obat yang relatif baru digunakan untuk menutup PDA jika dibandingkan dengan indometasin ataupun ibuprofen dengan tinkat keberhasilan yang tinggi.
Kata kunci: Patent ductus arteriosus (PDA), gangguan hemodinamik, parasetamol
Abstract
Patent ductus arteriosus (PDA) is a congenital disorder characterized by a failure to close the ductus arteriosus (DA) immediately after birth. The impact of not closing the DA will occur hemodynamic disturbances, aggravating other problems that accompany premature babies so that it will increase morbidity and mortality. Paracetamol is a relatively new drug used to close PDAs when compared with indomethacin or ibuprofen with the high success rates.
Keywords: Patent ductus arteriosus (PDA), hemodynamic problem, paracetamol
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References
Sari O, Nova R, Bermawi H, Bahar E, Anak BK, Sari O, et al. Perbandingan Efektifitas dan Keamanan Parasetamol Intravena dan Ibuprofen Oral pada Penutupan Duktus Arteriosus Persisten pada Bayi Kurang Bulan. 2015;17(4):279–84.
2. Rastogi S. Controversies in the Management of Patent Ductus Arteriosus in Preterm Journal of Neonatal Biology Controversies in the Management of Patent Ductus Arteriosus in Preterm Infants. 2016;(January).
3. Kliegman, Robert M., Stanton, Bonita F., Joseph, W.St Geme III., Nina FS. Nelson Text Book of Pediatrics. 20 Edition. Richard E. Behrman, editor. Philadelphia: Elsevier; 2016. 2197, Chapter 426 p.
4. Buck ML. Update on the Use of Acetaminophen for Patent Ductus Arteriosus Closure. Pediatr Pharmacother. 2018;24(5).
5. Bardanzellu F, Neroni P, Dessì A, Fanos V. Paracetamol in Patent Ductus Arteriosus Treatment : Efficacious and Safe ? 2017;2017.
6. Juniar I. Current Evidence in Pediatric Practices. Jakarta: FK UI; 21014. 100-109 p.
7. Loomba R, Nijhawan K. Ibuprofen Versus Indomethacin for Medical Closure of the Patent Arterial Duct : A Pooled Analysis by Route of Administration. Cureus. 2015;7(6).
8. Hardy A, Pharm D. Acetaminophen Use in Patent Ductus Arteriosus ( PDA ). 2016;1–20.
9. Abdel-hady H, Nasef N, Shabaan AE, Nour I. Patent Ductus Arteriosus in Preterm Infants : Do We Have the Right Answers ? Biomed Res Int. 2013;2013.
10. Dani C, Poggi C, Mosca F, Schena F, Lista G, Ramenghi L, et al. Efficacy and safety of intravenous paracetamol in comparison to ibuprofen for the treatment of patent ductus arteriosus in preterm infants : study protocol for a randomized control trial. Trials [Internet]. 2016;1–13. Available from: http://dx.doi.org/10.1186/s13063-016-1294-4
11. Hammerman, Cathy.,Alona Bin-Nun, Einat Markovitch, Michael S. Schimmel, Michael Kaplan and DF. Ductal Closure With Paracetamol : A Surprising New Approach to Patent Ductus Arteriosus Treatment abstract. Pediatrics. 2011;128, Numbe.
12. Allegaert K, Anderson B, Simons S, Overmeire B Van. Paracetamol to induce ductus arteriosus closure : is it valid ? 2013;462–6.
13. Sinha R, Negi V, Dalal SS. B rief R eport ››› An Interesting Observation of PDA Closure with Oral Paracetamol in Preterm Neonates. 2013;2(1):30–2.
14. Maria G, Allegaert K. Clinical Pharmacology of Paracetamol in Neonates : A Review. 2015;77:24–30.
15. Oncel, Mehmet Yekta, Sadik Yurttutan, Nurdan Uras, Nahide Altug, Ramazan Ozdemir, Sadrattin Ekmen et al. in the management of patent ibuprofen-resistant or infants An alternative drug ( paracetamol ) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. BMJ. 2012;2012–3.
16. Dart ARC, Barry H. Intravenous Acetaminophen in the United States : Iatrogenic Dosing Errors. 2012;129(2):349–53.
17. Ohlsson A, Walia R, Ss S. Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight ( or both ) infants ( Review ). 2015;(2).
18. Ohlsson A, Ps S. Paracetamol ( acetaminophen ) for patent ductus arteriosus in preterm or low birth weight infants ( Review ) SUMMARY OF FINDINGS FOR THE MAIN COMPARISON. 2018;(4).
19. Zecca E, Romagnoli C, Carolis MP De, Costa S, Marra R, Luca D De. Does Ibuprofen Increase Neonatal Hyperbilirubinemia ? 2009;
20. Terrin G, Conte F, Oncel MY, Scipione A, Mcnamara PJ, Simons S, et al. Paracetamol for the treatment of patent ductus arteriosus in preterm neonates : a systematic review and meta-analysis. 2015;
21. Yurttutan S, Oncel MY, Uras N, Altug N, Erdeve O, Dilmen U. A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol. 2013;7058(8):825–7.
22. Dang D, Wang D, Zhang C, Zhou W, Zhou Q, Wu H. Comparison of Oral Paracetamol versus Ibuprofen in Premature Infants with Patent Ductus Arteriosus : A Randomized Controlled Trial. 2013;8(11):1–5.
23. Terrin G, Conte F, Scipione A, Bacchio E, Conti MG, Ferro R, et al. OF PEDIATRICS Efficacy of paracetamol for the treatment of patent ductus arteriosus in preterm neonates. Ital J Pediatr [Internet]. 2014;40(1):1–4. Available from: Italian Journal of Pediatrics
24. Bagheri MM, Niknafs P, Sabsevari F, Torabi MH, Bijari BB, Noroozi E, et al. Comparison of Oral Acetaminophen Versus Ibuprofen in Premature Infants With Patent Ductus Arteriosus. 2016;26(4).
25. Nadir E, Kassem E, Foldi S, Hochberg A, Feldman M. Paracetamol treatment of patent ductus arteriosus in preterm infants. 2014;(April):1–2. Available from: http://dx.doi.org/10.1038/jp.2014.96
2. Rastogi S. Controversies in the Management of Patent Ductus Arteriosus in Preterm Journal of Neonatal Biology Controversies in the Management of Patent Ductus Arteriosus in Preterm Infants. 2016;(January).
3. Kliegman, Robert M., Stanton, Bonita F., Joseph, W.St Geme III., Nina FS. Nelson Text Book of Pediatrics. 20 Edition. Richard E. Behrman, editor. Philadelphia: Elsevier; 2016. 2197, Chapter 426 p.
4. Buck ML. Update on the Use of Acetaminophen for Patent Ductus Arteriosus Closure. Pediatr Pharmacother. 2018;24(5).
5. Bardanzellu F, Neroni P, Dessì A, Fanos V. Paracetamol in Patent Ductus Arteriosus Treatment : Efficacious and Safe ? 2017;2017.
6. Juniar I. Current Evidence in Pediatric Practices. Jakarta: FK UI; 21014. 100-109 p.
7. Loomba R, Nijhawan K. Ibuprofen Versus Indomethacin for Medical Closure of the Patent Arterial Duct : A Pooled Analysis by Route of Administration. Cureus. 2015;7(6).
8. Hardy A, Pharm D. Acetaminophen Use in Patent Ductus Arteriosus ( PDA ). 2016;1–20.
9. Abdel-hady H, Nasef N, Shabaan AE, Nour I. Patent Ductus Arteriosus in Preterm Infants : Do We Have the Right Answers ? Biomed Res Int. 2013;2013.
10. Dani C, Poggi C, Mosca F, Schena F, Lista G, Ramenghi L, et al. Efficacy and safety of intravenous paracetamol in comparison to ibuprofen for the treatment of patent ductus arteriosus in preterm infants : study protocol for a randomized control trial. Trials [Internet]. 2016;1–13. Available from: http://dx.doi.org/10.1186/s13063-016-1294-4
11. Hammerman, Cathy.,Alona Bin-Nun, Einat Markovitch, Michael S. Schimmel, Michael Kaplan and DF. Ductal Closure With Paracetamol : A Surprising New Approach to Patent Ductus Arteriosus Treatment abstract. Pediatrics. 2011;128, Numbe.
12. Allegaert K, Anderson B, Simons S, Overmeire B Van. Paracetamol to induce ductus arteriosus closure : is it valid ? 2013;462–6.
13. Sinha R, Negi V, Dalal SS. B rief R eport ››› An Interesting Observation of PDA Closure with Oral Paracetamol in Preterm Neonates. 2013;2(1):30–2.
14. Maria G, Allegaert K. Clinical Pharmacology of Paracetamol in Neonates : A Review. 2015;77:24–30.
15. Oncel, Mehmet Yekta, Sadik Yurttutan, Nurdan Uras, Nahide Altug, Ramazan Ozdemir, Sadrattin Ekmen et al. in the management of patent ibuprofen-resistant or infants An alternative drug ( paracetamol ) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. BMJ. 2012;2012–3.
16. Dart ARC, Barry H. Intravenous Acetaminophen in the United States : Iatrogenic Dosing Errors. 2012;129(2):349–53.
17. Ohlsson A, Walia R, Ss S. Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight ( or both ) infants ( Review ). 2015;(2).
18. Ohlsson A, Ps S. Paracetamol ( acetaminophen ) for patent ductus arteriosus in preterm or low birth weight infants ( Review ) SUMMARY OF FINDINGS FOR THE MAIN COMPARISON. 2018;(4).
19. Zecca E, Romagnoli C, Carolis MP De, Costa S, Marra R, Luca D De. Does Ibuprofen Increase Neonatal Hyperbilirubinemia ? 2009;
20. Terrin G, Conte F, Oncel MY, Scipione A, Mcnamara PJ, Simons S, et al. Paracetamol for the treatment of patent ductus arteriosus in preterm neonates : a systematic review and meta-analysis. 2015;
21. Yurttutan S, Oncel MY, Uras N, Altug N, Erdeve O, Dilmen U. A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol. 2013;7058(8):825–7.
22. Dang D, Wang D, Zhang C, Zhou W, Zhou Q, Wu H. Comparison of Oral Paracetamol versus Ibuprofen in Premature Infants with Patent Ductus Arteriosus : A Randomized Controlled Trial. 2013;8(11):1–5.
23. Terrin G, Conte F, Scipione A, Bacchio E, Conti MG, Ferro R, et al. OF PEDIATRICS Efficacy of paracetamol for the treatment of patent ductus arteriosus in preterm neonates. Ital J Pediatr [Internet]. 2014;40(1):1–4. Available from: Italian Journal of Pediatrics
24. Bagheri MM, Niknafs P, Sabsevari F, Torabi MH, Bijari BB, Noroozi E, et al. Comparison of Oral Acetaminophen Versus Ibuprofen in Premature Infants With Patent Ductus Arteriosus. 2016;26(4).
25. Nadir E, Kassem E, Foldi S, Hochberg A, Feldman M. Paracetamol treatment of patent ductus arteriosus in preterm infants. 2014;(April):1–2. Available from: http://dx.doi.org/10.1038/jp.2014.96
Published
2019-09-11
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How to Cite
Dimiati, H., & Fasli, R. (2019). PERANAN ACETAMINOPHEN (PARASETAMOL) DALAM PENUTUPAN DUCTUS ARTERIOSUS. Indonesian Journal of Cardiology, 39(3). https://doi.org/10.30701/ijc.v39i3.823
Section
Review Article
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