Transplantasi Sel Progenitor Endotel Pasca Infark Miokard

Abstract

Cedera dan disfungsi endotel merupakan kejadian yang mendasari patogenesis proses aterosklerosis, sehingga pemahaman terhadap mekanisme yang dapat mem-pertahan-kan maupun mengembalikan fungsi endotel tersebut mempunyai implikasi klinis yang penting.
Selain itu, tingkat kejadian gagal jantung kronis sebagai akibat penyakit jantung koroner masih tetap tinggi. Penyelamatan miokard dengan terapi perfusi dini terbukti dapat menurunkan angka mortalitas, namun gagal jantung pasca infark miokard akibat remodeling ventrikel masih menjadi masalah yang belum terpecahkan sepenuhnya.

Downloads

Download data is not yet available.

References

Rosenzweig A. Circulating endothelial progenitors – Cells as biomarkers. N Engl J Med 2005;353:1055-57.

Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction : Experimental observations and clinical implications. Circulation 1990;81:1161-72.

Assmus B, Honold J, Schachinger V et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006; 355:1222-32.

Lunde K, Solheim S, Aakhus S et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 2006;355:1199-209.

http://en.wikipedia.org/wiki/progenitor-cell. Progenitor cell. dikutip: 03/05/2007.

Asahara T, Murohara T, Sullivan A et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-6.

Rafii S, Shi BQ, Wu MH-D et al. Evidence for circulating bone marrow-derived endothelial cells. Blood 1998;92:362-7.

Lee MS, Makkar RR. Stem-cell transplantation in myocardial infarction: A status report. Ann Intern Med 2004;140:729-37.

Urbich C, Heeschen C, Aicher A et al. Relevance of monocytic features fot neovascularization capacity of circulating endothelial progenitor cells. Circulation 2003;108:2511-6.

Hill JM,Zalos G, Halcox JPJ et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348:593-600.

Werner N, Junk S, Laufs U et al. Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury. Circ Res 2003;93:e17-e24.

Szmitko PE, Fedak PWM, Weisel RD et al. Endothelial progenitor cells : New hope for a broken heart. Circulation 2003;107:3093-100.

Shintani S, Murohara T,Ikeda H et al. Mobilizationof endothelial progenitor cells in patients with acute myocardial infarction. Circulation 2001;103:2776-9.

Urbich C, Dimmeler S. Endothelial progenitor cells: Characterization and role in vascular biology. Circ Res 2004;95:343-53.

Quesenberry PJ, Becker PS. Stem cell homing: Rolling, crawling and nesting. Proc Natl Acad Sci 1998;95:1515-7.

Rosenzweig A, Endothelial progenitor cells. N Engl J Med 2003; 348:581-2.

Klaka C, Masuda H, Takahashi T et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci 2000;97:3422-7.

Orlic D, Kajstura J, Chimenti S et al. Mobilized bone marrow cells repair the infracted heart, improving function and survival. Proc Natl Acad Sci 2001;98:1034-9.

Rosenzweig A. Cardiac cell therapy-Mixed results from mixed cells. N Engl J Med 2006;355:1274-7

Reksodiputro AH. Transplantasi sel asal/induk darah. In: Sudoyo AW dkk. Buku ajar Ilmu Penyakit Dalam edisi IV Jakarta. Pusat penerbitan Departemen Ilmu Penyakit Dalam FKUI. 2006:755-8.

Min JY, Yang Y, Converso KL et al. Transplantation of embryonic stem cell improves cardiac function in postinfarcted rats. J Appl Physiol 2002;92:288-96.

Etzion S, Battler A, Barbash IM et al. Influence of embryonic cardiomyocyte transplantation on the progression of heart failure in rat model of extensive myocardial infarction. J Mol Cell Cardiol 2001;33:1321-30.

Saputra V. Dasar-dasar stem cell dan potensi aplikasinya dalam Ilmu Kedokteran. Cermin dunia kedokteran 2006;153:21-5.

Beeres SLMA, Atsma DE, Laarse Avd et al. Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomiocyte cultures. J Am Coll Cardiol 2005;46:1943-52.

Kocher AA, Schuster MD, Szabolcs MJ et al. Neovascularization of ischemic myocardium by human bone-marrow derived angioblasts prevents cardiomiocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001;7:430-6.

Strauer BE, Brehm M, Zeus T et al. Repair of infracted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002; 106:1913-8.

Seeger FH, Tonn T Krzossok N et al. Cell isolation procedures matter: A comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction. Eur Heart J 2007;28:766-72.

Kawamoto A, Gwon H-C, Iwaguro H et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation 2001;103:634-7.

Schachinger V, Erbs S, Elsasser A et al. Intarcoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006;355:1210-21.

Fuchs S, Baffour R, Zhou YF et al. Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. J Am Coll Cardiol 2001;37:1726-32.

Assmus B, Schachinger V, Teupe C et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation 2002; 106:3009-17.

Lunde K, Solheim S, Aakhus S et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 2006;355:1199-209.

Meyer GP, Wollert KC, Lotz J et al. Intracoronary bone marrow cell transfer after myocardial infarction. Circulation 2006;113:1287-94.

Janssens S, Dubois C, Bogaert J, et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segmen elevation myocardial infarction;double-blind, randomized controlled trial. Lancet 2006;367:113-21.
Views & Downloads
Abstract views: 57   
PDF (Bahasa Indonesia) downloads: 5   
How to Cite
Transplantasi Sel Progenitor Endotel Pasca Infark Miokard. (1). Indonesian Journal of Cardiology, 28(4), 297-302. https://doi.org/10.30701/ijc.v28i4.233
Section
Review Article