Drug Eluting Stent dan pemakaian Off-label
Abstract
Revaskulasisasi koroner dengan PCI (Percutaneous Coronary Intervention) merupakan suatu cara yang sudah diterima sebagai alternatif bedah dalam mengatasi Penyakit Jantung Koroner (PJK). Pemakaian Stent mempertinggi keberhasilan PCI namun tidak berhasil menghilangkan “the Achilles heel of PCI” berupa restenosis yang mengganjal keberhasilan jangka dekat dan panjang. Stent dengan penyalut obat (DES) berhasil mengurangi insidens restenosis menjadi amat kecil sehingga meningkatkan keberhasilan PCI dalam mengatasi PJK.Pemakaian DES kemudian amat meningkat dan menimbulkan kejadian fatal yang disebabkan karena kematian karena terjadinya trombosis. Sejak FDA di Amerika sekitar bulan Februari 2003 mengizinkan pemakaian DES dengan obat Sirolimus dan Paclitaxel, pemakaian DES diindikasikan hanya pada penderita2 tertentu dengan lesi de novodengan panjang < 30 mm dan diameter antara 2.5 sampai 3.5 mm sesuai dengan data2 yang didapat pada penelitian awal.
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References
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Joner M,Finn AV,Farb, dkk. Pathology of drug eluting stents in humans: Delayed healing and late thrombotic risk. J Am Coll Cardiol.2006; 48: 193-202.
Lee SW, Park SW, Hong MK, dkk. Triple versus dual antipletelt therapy after coronary stenting: Impact on stent thrombosis. J Am Coll Cardiol. 2005; 46: 1833-1837.
Aribowo DD, Tobing D, Sunanto Ng, Munawar M, Soerianata S. Implantasi drug-eluting stent atas indikasi off-label: Pengala-man dan luaran klinis di Pusat Jantung Nasional Harapan Kita. J Kardiol Indones. 2008;
Applegate RJ, Sacrinty MT, Kutcher MA, dkk. Off-label stent therapy: 2-year comparison of drug eluting versus bare metal stents. J Am Coll Cardiol. 2008; 51: 607-614.
Pfisterer ME for the BASKET-LATE Investigators. Late clinical events related to late stent thrombosis after stopping clopidogrel: Prospective randomized comparison between drug-eluting versus bare metal stenting. Abstract 422-American College of Cardiol-ogy 55th Annual Scientific Meeting; March 11-14, 2006. Atlanta Georgia.
Joner M,Finn AV,Farb, dkk. Pathology of drug eluting stents in humans: Delayed healing and late thrombotic risk. J Am Coll Cardiol.2006; 48: 193-202.
Lee SW, Park SW, Hong MK, dkk. Triple versus dual antipletelt therapy after coronary stenting: Impact on stent thrombosis. J Am Coll Cardiol. 2005; 46: 1833-1837.
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How to Cite
Rachman, O. (1). Drug Eluting Stent dan pemakaian Off-label. Indonesian Journal of Cardiology, 29(2), 80-81. https://doi.org/10.30701/ijc.v29i2.191
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