Secreted Left Atrial P-Selectin in Mitral Stenosis after PBMV: When to Measure
Abstract
The glycoprotein P-selectin, a membrane component of cell storage granules, is rapidly translocated from ?-granules of platelets and the Weibel- Palade bodies of endothelial cells to the cell surface following an inflammatory process or other stimulations. P-selectin is a cell adhesion molecule of activated platelets and endothelial cells of interest because of its role in modulating interactions between blood cells and the endothelium, and also because of the possible use of its soluble form in plasma as a predictor of adverse cardiovascular events.1In endothelial cells, within minutes of its stimulation in vitro by inflammatory mediators, such as histamine, thrombin, or phorbol esters, or hypoxia, Weibel–Palade bodies are mobilized and their von Willebrand factor are degranulated. At the same time, P-selectin is also expressed at the surface as quick astwo minutes after stimulation. However, this expressionis short-lived, reaching its peak after only 10 minutes, declining back to baseline levels after 3 hours. Additional synthesis of P-selectin is brought about within 2 hours by cytokines, such as interleukin-1 (IL-1), tumor necrosis factor-? (TNF-?), and by thrombin, lipopolysaccharide or oxygen radicals. Immunofluorescence and confocal laser cytometry are usually used to measure the translocation upon this activation.1
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References
1. Blann AD, Nadar SK, Lip GYH. The adhesion molecule P-selectin and cardiovascular disease. European Heart Journal. 2003;24: 2166–79.
2. McEver RP. Adhesive interactions of leukocytes, platelets, and thevessel wall during hemostasis and inflammation. ThrombHaemost2001;86:746–56.
3. Banu N, Avraham S, Avraham HK. P-selectin, and not E-selectin,negatively regulates murine megakaryocytopoiesis. J Immunol2002;169:4579–85.
4. Topaloglu S, Aras D, Ergun K, Geyik B, Ayaz S, Cay S, Cagirci G, Tufekcioglu O, Korkmaz S. Plasma level of soluble P-selectin in patients with rheumatic mitral stenosis and sinus rhythm undergoing percutaneous mitral balloon valvuloplasty. J Thromb and Thrombolysis 2007; 23: 199-204.
5. Hasan-Ali H, Mosad E. Changes in platelet, coagulation, and fibrinolytic activities in mitral stenosis after percutaneous mitral valvotomy: role of hemodynamic change and systemic inflammation. ClinApplThrombHemost 2014 may 19 pii-1076029614533144. [Epub ahead of print].
2. McEver RP. Adhesive interactions of leukocytes, platelets, and thevessel wall during hemostasis and inflammation. ThrombHaemost2001;86:746–56.
3. Banu N, Avraham S, Avraham HK. P-selectin, and not E-selectin,negatively regulates murine megakaryocytopoiesis. J Immunol2002;169:4579–85.
4. Topaloglu S, Aras D, Ergun K, Geyik B, Ayaz S, Cay S, Cagirci G, Tufekcioglu O, Korkmaz S. Plasma level of soluble P-selectin in patients with rheumatic mitral stenosis and sinus rhythm undergoing percutaneous mitral balloon valvuloplasty. J Thromb and Thrombolysis 2007; 23: 199-204.
5. Hasan-Ali H, Mosad E. Changes in platelet, coagulation, and fibrinolytic activities in mitral stenosis after percutaneous mitral valvotomy: role of hemodynamic change and systemic inflammation. ClinApplThrombHemost 2014 may 19 pii-1076029614533144. [Epub ahead of print].
Published
2015-11-19
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How to Cite
Rohman, M. S. (2015). Secreted Left Atrial P-Selectin in Mitral Stenosis after PBMV: When to Measure. Indonesian Journal of Cardiology, 35(3), 157-8. https://doi.org/10.30701/ijc.v35i3.428
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