Transient ischemic dilation as a diagnostic marker in myocardial perfusion SPECT protocols: a systematic review and meta-analysis
Background: Transient ischemic dilation (TID) measures left ventricle (LV) volume changes which can be associated with combination of myocardial and endocardial ischemia. Various stress methods, single photon emission computerized tomography (SPECT) imaging protocol, camera and software incite controversy on TID cut off. The purpose of this study was to evaluate the TID ratio in detection of coronary artery disease (CAD) categories in a systematic review and meta-analysis.
Method: We conducted a systematic search of electronic databases (PubMed, Scopus, Embase and Web of Science) up to 1 January 2017. The reference lists of all included studies were searched for a higher accuracy. The search strategy was according a defined PICO as P: none, I: Transient ischemic dilation, O: Coronary Artery Diseases, C: Angiographies. Statistical analysis was done by Comprehensive meta-analysis software version 2 (CMA-2).
Result: After study selection process, 7 studies were selected for data extraction. TID was studied from 1987. The sample size of included studies ranged between 86 and 545. The mean age of included patients varied between 58 and 69 years old. Ranges of TID in CAD categories were excluded. The pooled estimates of TID in single and dual pharmacological stress test in three CAD categories were calculated.
Conclusion: Our findings show that more studies are needed to compare the TID variability. Although in this study meta-analysis was done and TID was summarized from studies but the software differences were ignored.
2. McLaughlin MG, Danias PG. Transient ischemic dilation: A powerful diagnostic and prognostic finding of stress myocardial perfusion imaging. Journal of Nuclear Cardiology. 2002;9(6):663-7.
3. Xu Y, Arsanjani R, Clond M, Hyun M, Lemley M, Fish M, et al. Transient ischemic dilation for coronary artery disease in quantitative analysis of same-day sestamibi myocardial perfusion SPECT. Journal of Nuclear Cardiology. 2012;19(3):465-73.
4. Bestetti A, Bigi R, Terranova P, Lombardi F, Fiorentini C. Prognostic implications of stress-induced transient ischemic dilation of the left ventricle in patients with systolic dysfunction and fixed perfusion defects. International journal of cardiology. 2010;140(3):323-7.
5. Emmett L, Magee M, Freedman SB, Van der Wall H, Bush V, Trieu J, et al. The role of left ventricular hypertrophy and diabetes in the presence of transient ischemic dilation of the left ventricle on myocardial perfusion SPECT images. Journal of Nuclear Medicine. 2005;46(10):1596-601.
6. Mazzanti M, Germano G, Kiat H, Kavanagh PB, Alexanderson E, Friedman JD, et al. Identification of severe and extensive coronary artery disease by automatic measurement of transient ischemic dilation of the left ventricle in dual-isotope myocardial perfusion SPECT. Journal of the American College of Cardiology. 1996;27(7):1612-20.
7. Abidov A, Bax JJ, Hayes SW, Cohen I, Nishina H, Yoda S, et al. Integration of automatically measured transient ischemic dilation ratio into interpretation of adenosine stress myocardial perfusion SPECT for detection of severe and extensive CAD. Journal of Nuclear Medicine. 2004;45(12):1999-2007.
8. Katz J, Ruisi M, Giedd K, Rachko M. Assessment of transient ischemic dilation (TID) ratio in gated SPECT myocardial perfusion imaging (MPI) using regadenoson, a new agent for pharmacologic stress testing. Journal of Nuclear Cardiology. 2012;19(4):727-34.
9. Fallahi B, Beiki D, Fard-Esfahani A, Akbarpour S, Abolhassani A, Kakhki V, et al. The additive value of transient left ventricular dilation using two-day dipyridamole 99mTc-MIBI SPET for screening coronary artery disease in patients with otherwise normal myocardial perfusion: a comparison between diabetic and non-diabetic cases. Hellenic journal of nuclear medicine. 2010;13(3):246-52.
10. Golzar Y, Olusanya A, Pe N, Dua SG, Golzar J, Gidea C, et al. The significance of automatically measured transient ischemic dilation in identifying severe and extensive coronary artery disease in regadenoson, single-isotope technetium-99m myocardial perfusion SPECT. Journal of Nuclear Cardiology. 2015;22(3):526-34.
11. Petretta M, Acampa W, Daniele S, Petretta MP, Nappi C, Assante R, et al. Transient ischemic dilation in SPECT myocardial perfusion imaging for prediction of severe coronary artery disease in diabetic patients. Journal of Nuclear Cardiology. 2013;20(1):45-52.
12. Lester D, El-Hajj S, Farag AA, Bhambhvani P, Tauxe L, Heo J, et al. Prognostic value of transient ischemic dilation with regadenoson myocardial perfusion imaging. Journal of Nuclear Cardiology. 2016;23(5):1147-55.
13. Valdiviezo C, Motivala AA, Hachamovitch R, Chamarthy M, Navarro PC, Ostfeld RJ, et al. The significance of transient ischemic dilation in the setting of otherwise normal SPECT radionuclide myocardial perfusion images. Journal of Nuclear Cardiology. 2011;18(2):220-9.
14. Heston TF, Sigg DM. Quantifying transient ischemic dilation using gated SPECT. Journal of Nuclear Medicine. 2005;46(12):1990-6.
15. Abidov A, Berman DS. Transient ischemic dilation associated with poststress myocardial stunning of the left ventricle in vasodilator stress myocardial perfusion SPECT: True marker of severe ischemia? : Springer; 2005.
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