Revolusi Genomik dan Masa Depan Kardiologi (Preventif); Ilustrasi Kasus: Penyakit Jantung Koroner pada Kembar Identik
Abstract
The Simon Dack Lecture, salah satu sesi paling bergengsi dari pertemuan ilmiah tahunan The American College of Cardiologysecara berturut-turut menampilkan tiga pembicara dengan latar belakang yang berbeda, tetapi memberikan pesan yang senada dan saling memperkuat.Diawali pada tahun 2003, Dr. Eugene Braunwald, mahaguru kardiologi, memberikan pandangannya mengenai Cardiology: The Past, The Present and The Future; kemudian tahun 2005, Dr. Eric Topol, ahli jantung intervensi dari California, memberikan kuliah dengan judul The Genomic Basis of Myocardial Infarction, dan pada tahun 2006, Dr. Elizabeth Nabel, Direktur NHLBI (National Heart Lung and Blood Institute), menyampaikan visinya dengan topik Genomic Medicine and Cardiovascular Disease. Ketiga dedengkot kardiologi Amerika itu ternyata memiliki visi yang serupa dalam melihat kardiologi di masa depan: bahwa revolusi genomik akan memberikan kontribusi yang signifikan dalam perkembangan ilmu dan praktek kardiologi di masa yang akan datang.
Tulisan ini mencoba menyarikan perspektif ketiga tokoh kardiologi dunia tersebut, disertai ilustrasi kasus yang ada di tanah air untuk menggambarkan bahwa perspektif yang mereka berikan sangat relevan dengan situasi di tanah air, serta ditambah beberapa referensi terkini, untuk melihat masa depan kardiologi, utamanya kardiologi preventif.
Downloads
Download data is not yet available.
References
Braunwald E. The Simon Dack lecture. Cardiology: the past, the present, and the future. J Am Coll Cardiol. 2003;42:2031-41.
Topol EJ. Simon Dack Lecture. The genomic basis of myocardial infarction. J Am Coll Cardiol. 2005;46:1456-65.
Nabel E. The Simon Dack lecture. Genomic Medicine and Cardiovascular Disease. National Heart, Lung, and Blood Institute. 2006.
Fischer M, Broeckel U, Holmer S, Baessler A, Hengstenberg C, Mayer B, Erdmann J, Klein G, Riegger G, Jacob HJ, Schunkert H. Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction. Circulation. 2005;111:855-62.
Gullu AU, Kizilay M, Ates M, Akcar M. The comparison of angiographic lesions and clinical outcomes in identical twins. Interact Cardiovasc Thorac Surg. 2007;6:575-6.
Arnett DK, Baird AE, Barkley RA, Basson CT, Boerwinkle E, Ganesh SK, Herrington DM, Hong Y, Jaquish C, McDermott DA, O’Donnell CJ. Relevance of genetics and genomics for prevention and treatment of cardiovascular disease: a scientific statement from the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group. Circulation. 2007;115:2878-901.
O’Donnell CJ, Nabel E. Cardiovascular Genomics, Personalized Medicine, and the National Heart, Lung, and Blood Institute: Part I: The Beginning of an Era. Circ Cardiovasc Genet. 2008;1:51-57.
Simon T, Verstuyft C, Mary-Krause M, Quteineh L, Drouet E, Meneveau N, Steg PG, Ferrieres J, Danchin N, Becquemont L. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med. 2009;360:363-75.
Mega JL, Close SL, Wiviott SD, Shen L, Hockett RD, Brandt JT, Walker JR, Antman EM, Macias W, Braunwald E, Sabatine MS. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med. 2009;360:354-62.
Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Sigurdsson A, Baker A, Palsson A, Masson G, Gudbjartsson DF, Magnusson KP, Andersen K, Levey AI, Backman VM, Matthiasdottir S, Jonsdottir T, Palsson S, Einarsdottir H, Gunnarsdottir S, Gylfason A, Vaccarino V, Hooper WC, Reilly MP, Granger CB, Austin H, Rader DJ, Shah SH, Quyyumi AA, Gulcher JR, Thorgeirsson G, Thorsteinsdottir U, Kong A, Stefansson K. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007;316:1491-3.
Tsai CT, Lai LP, Hwang JJ, Lin JL, Chiang FT. Molecular genetics of atrial fibrillation. J Am Coll Cardiol. 2008;52:241-50.
A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure. N Engl J Med. 2001;344:1659-67.
O’Connor C, Anand I, Fiuzat M. Additive effects of beta-1 389 Arg/Gly and alpha-2c 322-325 wild-type/del genotype combinations on adjudicated hospitalizations and death in the Beta Blocker Evaluation of Survival Trial (BEST). Heart Failure Society of America 2008 Scientific Meeting. 2008;Abstract 216.
Topol EJ. Simon Dack Lecture. The genomic basis of myocardial infarction. J Am Coll Cardiol. 2005;46:1456-65.
Nabel E. The Simon Dack lecture. Genomic Medicine and Cardiovascular Disease. National Heart, Lung, and Blood Institute. 2006.
Fischer M, Broeckel U, Holmer S, Baessler A, Hengstenberg C, Mayer B, Erdmann J, Klein G, Riegger G, Jacob HJ, Schunkert H. Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction. Circulation. 2005;111:855-62.
Gullu AU, Kizilay M, Ates M, Akcar M. The comparison of angiographic lesions and clinical outcomes in identical twins. Interact Cardiovasc Thorac Surg. 2007;6:575-6.
Arnett DK, Baird AE, Barkley RA, Basson CT, Boerwinkle E, Ganesh SK, Herrington DM, Hong Y, Jaquish C, McDermott DA, O’Donnell CJ. Relevance of genetics and genomics for prevention and treatment of cardiovascular disease: a scientific statement from the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group. Circulation. 2007;115:2878-901.
O’Donnell CJ, Nabel E. Cardiovascular Genomics, Personalized Medicine, and the National Heart, Lung, and Blood Institute: Part I: The Beginning of an Era. Circ Cardiovasc Genet. 2008;1:51-57.
Simon T, Verstuyft C, Mary-Krause M, Quteineh L, Drouet E, Meneveau N, Steg PG, Ferrieres J, Danchin N, Becquemont L. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med. 2009;360:363-75.
Mega JL, Close SL, Wiviott SD, Shen L, Hockett RD, Brandt JT, Walker JR, Antman EM, Macias W, Braunwald E, Sabatine MS. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med. 2009;360:354-62.
Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Sigurdsson A, Baker A, Palsson A, Masson G, Gudbjartsson DF, Magnusson KP, Andersen K, Levey AI, Backman VM, Matthiasdottir S, Jonsdottir T, Palsson S, Einarsdottir H, Gunnarsdottir S, Gylfason A, Vaccarino V, Hooper WC, Reilly MP, Granger CB, Austin H, Rader DJ, Shah SH, Quyyumi AA, Gulcher JR, Thorgeirsson G, Thorsteinsdottir U, Kong A, Stefansson K. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007;316:1491-3.
Tsai CT, Lai LP, Hwang JJ, Lin JL, Chiang FT. Molecular genetics of atrial fibrillation. J Am Coll Cardiol. 2008;52:241-50.
A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure. N Engl J Med. 2001;344:1659-67.
O’Connor C, Anand I, Fiuzat M. Additive effects of beta-1 389 Arg/Gly and alpha-2c 322-325 wild-type/del genotype combinations on adjudicated hospitalizations and death in the Beta Blocker Evaluation of Survival Trial (BEST). Heart Failure Society of America 2008 Scientific Meeting. 2008;Abstract 216.
Views & Downloads
Abstract views: 2546
PDF (Bahasa Indonesia) downloads: 2179
PDF (Bahasa Indonesia) downloads: 2179
How to Cite
Raharjo, S., Joesoef, A., & Setianto, B. (1). Revolusi Genomik dan Masa Depan Kardiologi (Preventif); Ilustrasi Kasus: Penyakit Jantung Koroner pada Kembar Identik. Indonesian Journal of Cardiology, 30(2), 80-5. https://doi.org/10.30701/ijc.v30i2.167
Section
Case Reports
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
