Peran Fibrinogen dan hs-CRP sebagai biomarker pada Penyakit Jantung Koroner
Abstract
Sindroma Koreoner Akut (SKA) yang merupakan penyebab kematian utama dari Penyakit Jantung Koroner (PJK) adalah suatu sindroma yang kompleks dengan penyebab multiple, sehingga upaya pengobatan akan lebih efektif jika ditujukan pada penyebab yang mendasarinya. Penyebab utama SKA meliputi: (1) adanya rupture plak disertai trombosis akut, (2) obstruksi mekanik yang progresif, (3) inflamasi, (4) adanya angina tak stabil sekunder dan (5) adanya obstruksi yang dinamik (vaso-konstriksi).1 Masing-masing penyebab ini saling menyumbang dan memberikan gambaran klinis yang berbeda satu sama lain sesuai dengan variasi kombinasi penyebab. Keadaan itu mempengaruhi strategi pengobatan yang berbeda pula. Pemberian vasodilator seperti nitrat, obat penyekat kalsium amat berguna jika penyebab utamanya suatu vasokonstriksi dinamik. Pemberian statin yang berfungsi sebagai antiinflamasi mungkin dapat berguna pada penderita dengan komponen inflamasi yang dominan.Downloads
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References
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Ang L, Khalid bin Tani, Ilapakurti M et al. Elevated plasma fibrinogen rather than residual platelet reactivity after clopidogrel pre-treatment is associated with an increased ischemic risk during elective percutaneous Coronary intervention. J Am Coll Cardiol. 2013;61:23-34.
Morrow DA. Troponins in patients with acute coronary syndromes: biologic, diagnostic and therapeutic implications. Cardiovasc Toxicol. 2002;1:105-110.
Pasceri V, Willerson JT, Yeh ET. Direct pro-inflammatory effect of C reactive protein on human endothelial cells. Circulation.2000;102:2165-2168.
Hamm CW. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2011; 32:2999–3054.
Kannel WB, Wolf PA, Castelli WP, D’Agostino RB. Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA. 1987;258:1183-1186.
Coppola G, Rizzo M, Abrignani MD et al. Fibrinogen as a predictor of mortality after acute myocardial infarction: a forty two-month follow up study. Ital Heart J. 2005;6:315-322.
Ziakas A, Givrilidis S, Giannoglou G et al. In hospital and long-term prognostic value of fibrinogen, CRP and IL-6 levels in patients with acute myocardial infarction treated with thrombolysis. Angiology. 2006;57:283-293.
Kaptoge S, Di Angelantonio E, Pennels L et al. C reactive protein, fibrinogen, and cardiovascular disease prediction.N Eng J Med 2012;367:1310-1320.
The accuracy of Fibrinogen and hs-CRP as a biomarker in acute Coronary syndromes (ACS). J Kardiol Indones. 2014.
Ang L, Khalid bin Tani, Ilapakurti M et al. Elevated plasma fibrinogen rather than residual platelet reactivity after clopidogrel pre-treatment is associated with an increased ischemic risk during elective percutaneous Coronary intervention. J Am Coll Cardiol. 2013;61:23-34.
Published
2015-03-31
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How to Cite
Rachman, O. (2015). Peran Fibrinogen dan hs-CRP sebagai biomarker pada Penyakit Jantung Koroner. Indonesian Journal of Cardiology, 35(1), 12-3. https://doi.org/10.30701/ijc.v35i1.370
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