Mechanisms of Atrial Fibrillation in Hyperthyoid

Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia other than sinus tachycardia encountered in hyperthyroidism and representing an independent risk factor for cardiovascular event. Atrial fibrillation occurs in 10-15% of patient with hyperthyroidism, where as prevalence increase with advancing age. The heart is a major target organ for thyroid hormone action. Thyroid hormones exert their cardiovascular effects either directly at cardiomiosit through nuclear receptors (gen transcription) and extra nuclear (cellular) which is influence inotropic, chronotropic and dromotropic effect and indirectly by influencing sympatoadrenergic system and altering peripheral hemodynamic. Hyperthyroidism is associated with an increased supraventricular ectopic activity. Hyperthyroidism increases the rate of systolic depolarization and diastolic repolarization, decreases the duration of the action potential and refraction period of the atrial myocardium, as well as atrioventricular nodal therefore facilitated the occurrence of atrial fibrillation.

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References

Jayaprasad N, Francis J. Atrial Fibrillation and Hyperthyroidism. Indian Pacing and Electrophysiology Jour:2005;305-11

Dabrowa AB, Mikhailidis DP, Rysz J, Banach M. The mechanisms of atrial fibrillation in hyperthyroidism : Thyroid Research; 2009/1756-6614-2-4

Kahaly GJ, Dillmann WH. Thyroid hormone action in the heart. Endocrine Review:2005;704-728

Klein I, Danzi S. Thyroid disease and the heart. Circ 2007;116:1725-35

Fazio S, Palmieri EA, Lombardi G, Biondi B. Effects of Thyroid Hormone on the Cardiovascular System

Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Eng J Med 2001;344 : 501-507.

Kanj M, Saliba W. Basic arrhythmia physiology and mechanism. In :Handbook of Cardiac Electrophysiology. Informa UK Ltd. 2007; 3-12.

Bosch R, Nattel S. Cellular electrophysiology of atrial fibrillation. 2002;54: 259-269.

Wustmann K, Kucera JP, Zanchi A, Burow A, Stuber T, Chappuis B, Diem P, Delacretaz E: Activation of Electrical Triggers of Atrial Fibrillation in Hyperthyroidism. J Clin Endocrinol Metab 2008, 93:2104-2108

Chen YC, Chen SA, Chen YJ, Chang MS, Chan P, Lin CI: Effects of thyroid hormone on the arrhythmogenic activity of pulmonary vein cardiomyocytes. J Am Coll Cardiol 2002, 39:366-372.

Sun Zq, Ojamas K,Coetze WA. Effect of Thyroid hormone on action potential and repolarization in rat ventricular myocytes. Am J Physiol 2000;27:302-7

Kim D, Smith TW. Effect of thyroid hormone on sodium pump sites, sodium content, and contractile response to cardiac glycosides in cultured chick ventricular cells. J Clin Invest 1984,74:1481-1488.

Nattel S: New ideas about atrial fibrillation 50 years .Nature 2002, 415:219-226.

Li D, Zhang L, Kneller J, Nattel S: Potential ionic mechanism for repolarization differences between canine right and left atrium. Circ Res 2001, 88:1168-1175.

Hu Y, Jones SV, Dillmann WH: Effects of hyperthyroidism on delayed rectifier potassium currents in left and right murine atrium. Am J Physiol Heart Circ Physiol 2005, 289:1448-1455.

Panagolis C, Halapas C, Halapas A, Chariatis E, Driva P, Matsakas E. Hyperthyroidism and the heart. Hellenic J Cardiol 2008;49:169-175

Khairy P, Nattel S. New insight into the mechanism and management of atrial fibrillation.CMAJ 2002;167: 1012-30
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How to Cite
Mechanisms of Atrial Fibrillation in Hyperthyoid. (1). Indonesian Journal of Cardiology, 32(3), 192-8. https://doi.org/10.30701/ijc.v32i3.98
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Review Article