Biomarker untuk hipertrofi ventrikel kiri
Abstract
Dampak peningkatan kronis tekanan darah arterial terhadap jantung merupakan respons dari ventrikel kiri terhadap beban tekanan yang berlebihan (pressure overload) dan rangsangan neurohumoral. Disamping hipertrofi sel-selotot jantung (cardiac myocyte) yang mengakibatkan hipertrofi ventrikel kiri (LVH) juga terjadi perubahan-perubahan pada komponen non cardiac myocyte otot jantung berupa apoptosis, fibrosis, dan perubahan-perubahan mikro-sirkulasi yang dipengaruhi hormon, growth factors, cy-tokines, molekul-molekul proinflammatory, sehingga terjadi pathologic myocardial remodeling.Remodeling otot jantung dapat disebabkan infark miokard, beban tekanan (pressure overload) maupun beban volume (volume overload), dan cardiomyopa-thy. Remodeling miokard akibat hipertensi mencakup peningkatan apoptosis miosit, fibrosis interstitial and perivasculer dan perubahan-perubahan mikrosirkulasi sehingga terjadi perubahan struktur maupun fungsi miokard berupa hipertrofi ventrikel kiri, peningkatan massa ventrikel kiri dan disfungsi ventrikel
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References
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Yamaguchi H, Yoshida J, Yamamoto K, et al. Elevation of BNP is a hallmark of patients with or at risk of Diastolic Heart Failure independent of ventricular hypertrophy. J Am Coll Cardiol. 2004; 43: 55-60.
Satyan S, Light RP, Agarwal R, et al. Relationships of N-ter-minal pro-B-natriuretic peptide and cardiac troponin T to left ventricular mass and function and mortality in asymptomatic hemodialysis patients. Am J Kidney Dis. 2007; 50: 1009-19.
Diez J, Frohlich ED. A translational approach to hypertensive heart disease. Hypertension.2010; 55:1-8.
Munir A, Sargowo D. N-Terminal proBrain Natriuretic Peptide sebagai petanda adanya hipertrofi ventrikel kiri pada pasien hipertensi dibandingkan left ventricle mass index pada ekokar-diografi. J Kardiol Indones. 2010; 31:87-98
Talwar S, Siebenhofer A, Williams B, Ng L. Influence of hypertension,left ventricular hypertrophy,and left ventricular dysfunction on plasma N terminal proBNP. Heart. 2000; 83: 278-82.
Ceyhan C, Unal S, Yenisey C, Tekten T, CeyhanFB. The role of N terminal pro-brain natriuretic peptide in the evaluation of left ventricular diastolic dysfunctio: correlation with echocar-diographic indexes in hypertensive patients. Int J Cardiovasc Imaging. 2008; 24: 253-9.
Paulus WJ, Tschöpe C, Sanderson JE, et al. How to diagnose heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J. 2007; 28: 1-12.
Magnusson M, Jovinge S, Rydberg E, et al. Natriuretic peptides as indicators of cardiac remodeling in hypertensive patients. Blood Pressure. 2009; 18: 196-203.
de Lemos JA, McGuire DK, Khera A, et al. Screening the population for left ventricular hypertrophy and left ventricular systolic dysfunction using natriuretic peptides:Results from the Dallas Heart Study. Am Heart J. 2009; 157: 746-753.e2.
Yamaguchi H, Yoshida J, Yamamoto K, et al. Elevation of BNP is a hallmark of patients with or at risk of Diastolic Heart Failure independent of ventricular hypertrophy. J Am Coll Cardiol. 2004; 43: 55-60.
Satyan S, Light RP, Agarwal R, et al. Relationships of N-ter-minal pro-B-natriuretic peptide and cardiac troponin T to left ventricular mass and function and mortality in asymptomatic hemodialysis patients. Am J Kidney Dis. 2007; 50: 1009-19.
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How to Cite
Soenarta, A. (1). Biomarker untuk hipertrofi ventrikel kiri. Indonesian Journal of Cardiology, 31(2), 99-100. https://doi.org/10.30701/ijc.v31i2.141
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