Potency of Xanthoneon Oxidant and Antioxidant Status in Atherosclerosis Rats
Abstract
Introduction. Xanthones, which have potent antioxidative and antiinflammatory, and various other bioactivities, are rich in a tropical fruit tree, mangosteen, Garcinia mangostana. The effect of xanthoneson oxidant level and antioxidant activity in hypercholesterolemic rats is still unknown.Objectives. To clarify an effect of xanthoneson oxidant level and antioxidant activity in hypercholesterolemic rats.
Methods. A total of 32 Wistar rats were divided into four groups (n=8), include control, hypercholesterolemic diet groups, hypercholesterolemic diet + xanthoneat dose 35; 70; and 140 mg/kg body weight. Control group receive standart diet for 60 days. Hypercholesterolemic diet group receive standart diet plus yellow egg, sheep oil, cholic acid, and pig oil for 60 days per oral. Analysis of blood hydrogen peroxide level, aorta glutathione peroxidase activity, and aorta catalase activity, were done using spectrophotometric.
The ANOVA test were used to analyze the different levels of hydrogen peroxide, glutahione peroxidase activity, and catalase activity.
Result. Hypercholesterolemic diet increase blood hydrogen peroxide level significantly compared to control group (p<0.05). Xanthone decrease blood hydrogen peroxide level significantly at all dose compared to control group (p<0.05). There is no significant difference of aorta glutahione peroxidase activity in all groups (p>0.05). Xanthone modulate an activity of catalase in aorta at dose 140 mg/kg body weight.
Conclusion. Xanthone has potency to decreaseblood oxidant level and modulate aorta catalase activity.
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References
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Weecharangsan W, Opanasopit P, Sukma M, Ngawhirun-pat T, Sotanaphun U, Siripong, P. 2006. Antioxidative and neuroprotective activities of extracts from the fruit hull of
mangosteen (Garcinia mangostana Linn.). Med Princ Practice; 15:281–287.
Droge W. 2002. Free radicals in the physiological control of cell function. Physiol Rev; 82:47-95.
Forbes JM, Coughlan MT, Cooper EM. 2008. Oxidativestress as a major culprit in kidney disease in diabetes. Diabetes; 57:1446-1554.
Madamanchi NR, Vendrov A, Runge MS. 2004. Oxidative stress and vascular disease. Arteriosclerosis Thromb Vasc Biology; 25:29-38.
Pe´rez-Rojas JM, Cruz C, Garcia-Lopez P, Sanchez-Gonzalez DJ, Martinez-Martinez CM, Ceballos G, Espinosa M, Me-lendez- Zajgla J, Pedraza-Chaverri J. 2009 Renoprotection by
a-mangostin is related to the attenuation in renal oxidative/nitrosative stress induced by cisplatin nephrotoxicity. Free Radic Res; 43:1122–1132.
Chin YW, Jung HA, Chai H, Keller WJ, Kinghorn AD. 2008. Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen). Phytochemistry;69:754–758.
Kaomongkolgit R, Jamdee K, Chaisomboon N. 2009. Antifun-gal activity of alpha mangostin against candida albicans. J Oral Sci; 51(3):401-406.
Chomnawang MT, Surassmo S, Nukoolkarn VS, Gritsanapan W. 2007. Effect of Garcinia mangostana on inflammation caused by propionibacterium acnes. Fitoterapia; 78: 401–408.
Chen LG, Yang LL, Wang CC. 2008. Anti-inflammatory activity of mangostins from Garcinia mangostana. Food Chem Toxicol; 46:688–693.
Han A, Kim J, Lantvit DD, Kardono LBS, Riswan S, Chai H, Blando EJC, Farnsworth NR, swanson SM, Kinghorn AD. 2009. Cytotoxic xanthone constituents of the stem bark of garcinia mangostana (mangosteen). J Nat Prod; 72(11):2028-2031.
Williams P, Ongsakul M, Proudfoot J, Croft, K, Beilin L. 1995. Mangostin inhibits the oxidative modification of human low density lipoprotein. Free Rad Res; 23:175–184.
Mahabusarakam W, Proudfoot J, Taylor W, Croft K. 2000. Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin. Free Rad Res; 33: 643–659.
Buelna-Chontal M, Correa F, Hernandez-Resendiz S, Zazueta C, Pedraza-Chaverri J. 2011. Protective effect of a-mangostin on cardiac reperfusion damage by attenuation on oxidative stress. J Med Food; 14(11):1370-1374.
Zadernowksi R, Czaplicki S, Naczk M. 2009. Phenolic acid profiles of mangosteen fruits (Garcinia mangostana).Food Chem; 112:685-689.
Pedraza-Chacerri J, Cardenas-Rodriguez N, Orozco-Ibarra M, Perez-Rojas JM. 2008. Medicine properties of mangosteen (Garcinia mangostana). Food Chem Toxicol; 46 :3227-3239.
Weecharangsan W, Opanasopit P, Sukma M, Ngawhirun-pat T, Sotanaphun U, Siripong, P. 2006. Antioxidative and neuroprotective activities of extracts from the fruit hull of
mangosteen (Garcinia mangostana Linn.). Med Princ Practice; 15:281–287.
Droge W. 2002. Free radicals in the physiological control of cell function. Physiol Rev; 82:47-95.
Forbes JM, Coughlan MT, Cooper EM. 2008. Oxidativestress as a major culprit in kidney disease in diabetes. Diabetes; 57:1446-1554.
Madamanchi NR, Vendrov A, Runge MS. 2004. Oxidative stress and vascular disease. Arteriosclerosis Thromb Vasc Biology; 25:29-38.
Pe´rez-Rojas JM, Cruz C, Garcia-Lopez P, Sanchez-Gonzalez DJ, Martinez-Martinez CM, Ceballos G, Espinosa M, Me-lendez- Zajgla J, Pedraza-Chaverri J. 2009 Renoprotection by
a-mangostin is related to the attenuation in renal oxidative/nitrosative stress induced by cisplatin nephrotoxicity. Free Radic Res; 43:1122–1132.
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How to Cite
Adiputro, D., Widodo, M., Romdoni, R., & Sargowo, D. (1). Potency of Xanthoneon Oxidant and Antioxidant Status in Atherosclerosis Rats. Indonesian Journal of Cardiology, 33(4), 209-14. https://doi.org/10.30701/ijc.v33i4.22
Section
Clinical Research
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