Pengembangan Riset Kardiovaskular: Quo Vadis Indonesia?
Abstract
Saat ini, derajat kesehatan masyarakat dunia meningkat beberapa kali lipat dibanding setengah abad yang lalu. Tentunya banyak faktor yang mempengaruhi, namun menurut WHO dan World Development Report ada dua kontributor terpenting yang tingkat peranannya setara (50% - 50%). Faktor pertama adalah meningkatnya tingkat pendidikan dan tingkat ekonomi masyarakat, sedangkan kontributor kedua adalah penemuan baru, pengetahuan baru serta pengembangan alat-alat baru (diagnostik, obat-obatan dan vaksin).Sementara itu, di Amerika Serikat sendiri, dikatakan bahwa mening-katnya usia harapan hidup sampai 25 tahun dalam satu abad terakhir ini, serta membaiknya kualitas hidup masyarakatnya sangat ditentukan oleh penemuan dan pengetahuan baru dari riset biomedis. Dan, semua mafhum bahwa pengetahuan dan penemuan baru tidak mungkin terwujud tanpa adanya investasi yang besar dan kontinyu dalam bidang riset.
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References
World Health Organization. The World Health Report 2000: Health Systems: Improving Performance. Geneva, Switzerland. World Health Organization; 2000.
Michaud CM, Murray CJL, Bloom BR. Burden of Disease – Implications for Future Research. JAMA 2001;285:535-539.
Vezina C, Kudelski A, Sehgal SN. Rapamycin (AY-22,989), a new antifungal antibiotic, I:toxoneme of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 1975;28:721-726.
Sehgal SN, Baker H, Vezina C. Rapamycin (AY-22,989), a new antifungal antibiotic, II: Fermentation, isolation and characterization. J Antibiot (Tokyo) 1975;28:727-732.
Marx SO, Jayaraman T, Go LO et al. Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells. Circ Res 1995;76:412-417.
Gallo R, Padurean A, Chesebro JH, et al. Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by rapamycin. Circulation 1998;99:2164-2170.
Sousa JE, Costa MA, Abizaid A et al. Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries. Circulation 2001;103:192-195.
Goldstein JL, Brown MS. The clinical investigator: bewitched, bothered, and bewildered – but still beloved. J Clin Invest 1997;99:2803-2812.
Schwartz P, Gaulton GN. Addressing the needs of basic and clinical research: Analysis of graduates of the University of Pennsylvania MD-PhD Program. JAMA;1999:96-97.
Kassirer JP. Academic medical center under siege. N Engl J Med 1994;331:1370-1371.
Michaud CM, Murray CJL, Bloom BR. Burden of Disease – Implications for Future Research. JAMA 2001;285:535-539.
Vezina C, Kudelski A, Sehgal SN. Rapamycin (AY-22,989), a new antifungal antibiotic, I:toxoneme of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 1975;28:721-726.
Sehgal SN, Baker H, Vezina C. Rapamycin (AY-22,989), a new antifungal antibiotic, II: Fermentation, isolation and characterization. J Antibiot (Tokyo) 1975;28:727-732.
Marx SO, Jayaraman T, Go LO et al. Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells. Circ Res 1995;76:412-417.
Gallo R, Padurean A, Chesebro JH, et al. Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by rapamycin. Circulation 1998;99:2164-2170.
Sousa JE, Costa MA, Abizaid A et al. Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries. Circulation 2001;103:192-195.
Goldstein JL, Brown MS. The clinical investigator: bewitched, bothered, and bewildered – but still beloved. J Clin Invest 1997;99:2803-2812.
Schwartz P, Gaulton GN. Addressing the needs of basic and clinical research: Analysis of graduates of the University of Pennsylvania MD-PhD Program. JAMA;1999:96-97.
Kassirer JP. Academic medical center under siege. N Engl J Med 1994;331:1370-1371.
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How to Cite
Raharjo, S. (1). Pengembangan Riset Kardiovaskular: Quo Vadis Indonesia?. Indonesian Journal of Cardiology, 28(2), 82-84. https://doi.org/10.30701/ijc.v28i2.249
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