The Effects of Short-Term, Low-Intensity Exercise Training on the Levels of High-Sensitive C-Reactive Protein in Patients with Acute Myocardial Infarction
Abstract
Background. Inflammation process plays an important role in the mechanism of acute coronary syndrome (ACS). High-sensitive C-reactive protein (hs-CRP) is an inflammatory marker and a strong predictor for cardiovascular events in patients with ACS. Previous studies have shown that half of the patients with ACS has high levels of hsCRP. This study aim to prove that the short-term, low-intensity exercise training will reduce the plasma levels of hs-CRP in patients with acute myocardial infarction.Methods and results.Thirty two male patients with acute myocardial infarction were randomized into 2 groups. The first group acquired programmed exercise training with low intensity for 5 days, while the control group did not get exercise training. Before and after this exercise training, all patients in both group did treadmill test with modified Bruce protocol. Plasma hs-CRP was examined before and after the treatment. The baseline characteristics of patients in both groups did not differ significantly. There was no significant different in the baseline levels of hs-CRP between treatment and control groups. Treadmill test significantly decreased the hs-CRP levels in both groups. Although exercise training also reduced hs-CRP levels, the reduction of hs-CRP were not different between treatment group and controls.
Conclusions. This study showed that short-term, low-intensity exercise training has no effect on the levels of hs-CRP in patients with acute myocardial infarction.
Downloads
Download data is not yet available.
References
Bradford C. Berk, MD, PhD, William S. Weintraub, MD, R. Wayne Alexander, MD, PhD. Elevation of C-Reactive Protein in “Active” Coronar y Arter y Disease. Am J Cardiol 1990;65:168-72
Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB, et al. The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Eng J Med 1994;331:417-24
Ridker PM, Buring JE, Shih J, Matias M, Hennekens CH. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 1998;98:731-33
Anzai T, Yoshikawa T, Shiraki H, Asakura Y, Akaishi M, Mitamura H, et al. C-Reactive protein asa a predictor of infarct expansion and cardiac rupture after a first Q-wave acute myocardial infarction. Circulation 1997;96:778-84
Beer FC, Hind CRK, Fox KM, Allan RM, Maseri A, Pepys MB. Measurement of serum C-reactive protein concentration in myocardial ischaemia and infarction. Br Heart J 1982;47:239-43
Biasucci LM, Liuzzo G, Grillo RL, Caligiuri G, Rebuzzi AG, Buffon A, et all. Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. Circulation 1999;99:855-60
Patel VB, Robbins MA, Topol EJ. C-reactive protein: a ’golden marker’ for inflammation and coronary artery disease. Cleve Clin J Med 2001;68:521-34
Nissen SE, Tuzcu EM, Schoenhagen P, Crowe T, Sasrela WJ, Tsai J, et al. Statin therapy and coronary artery disease. N Engl J Med 2005;352:29-38
Ridker PM, Cannon CP, Morrow D, Rifai N, Rose LM, McCabe CH, et al. C-reactive protein levels and outcome after statin therapy. N Eng J Med 2005;352:20-8
Niclas BJ, You T, Pahor M. Behavioural treatments for chronic systemic inflammation : effect of dietary weight loss and exercise training. CMAJ 2005;172(9):119-209
Vasapis C, Thompson PD. The effect of physical activity on serum C-reactive protein and inflammatory markers. A systemic review. J Am Coll Cardiol 2005;45:1563-9
Vincent HK, Powers SK, Stewart DJ, Demirel HA, Shanely FA, Naito H. Short-term exercise training improves diaphragm antioxidant capacity and endurance. Eur J Appl Physiol 2000;81:67-74
Adamopoulus S, Parissis J, Kroupis C, Georgiadis M, Karatzas D, Karavolias G, et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 2001;22:791-7
Powers SK, Ji LL, Leeuwenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Med Sci Sports Exerc 1999;31:987-97
Esposito K, Pontillo A, Di Palo C, et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 2003;289:1799-804
Abramson JL, Vaccarino V. Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults. Arch Intern Med 2002;162:1286-9
Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB, et al. The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Eng J Med 1994;331:417-24
Ridker PM, Buring JE, Shih J, Matias M, Hennekens CH. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 1998;98:731-33
Anzai T, Yoshikawa T, Shiraki H, Asakura Y, Akaishi M, Mitamura H, et al. C-Reactive protein asa a predictor of infarct expansion and cardiac rupture after a first Q-wave acute myocardial infarction. Circulation 1997;96:778-84
Beer FC, Hind CRK, Fox KM, Allan RM, Maseri A, Pepys MB. Measurement of serum C-reactive protein concentration in myocardial ischaemia and infarction. Br Heart J 1982;47:239-43
Biasucci LM, Liuzzo G, Grillo RL, Caligiuri G, Rebuzzi AG, Buffon A, et all. Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. Circulation 1999;99:855-60
Patel VB, Robbins MA, Topol EJ. C-reactive protein: a ’golden marker’ for inflammation and coronary artery disease. Cleve Clin J Med 2001;68:521-34
Nissen SE, Tuzcu EM, Schoenhagen P, Crowe T, Sasrela WJ, Tsai J, et al. Statin therapy and coronary artery disease. N Engl J Med 2005;352:29-38
Ridker PM, Cannon CP, Morrow D, Rifai N, Rose LM, McCabe CH, et al. C-reactive protein levels and outcome after statin therapy. N Eng J Med 2005;352:20-8
Niclas BJ, You T, Pahor M. Behavioural treatments for chronic systemic inflammation : effect of dietary weight loss and exercise training. CMAJ 2005;172(9):119-209
Vasapis C, Thompson PD. The effect of physical activity on serum C-reactive protein and inflammatory markers. A systemic review. J Am Coll Cardiol 2005;45:1563-9
Vincent HK, Powers SK, Stewart DJ, Demirel HA, Shanely FA, Naito H. Short-term exercise training improves diaphragm antioxidant capacity and endurance. Eur J Appl Physiol 2000;81:67-74
Adamopoulus S, Parissis J, Kroupis C, Georgiadis M, Karatzas D, Karavolias G, et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 2001;22:791-7
Powers SK, Ji LL, Leeuwenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Med Sci Sports Exerc 1999;31:987-97
Esposito K, Pontillo A, Di Palo C, et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 2003;289:1799-804
Abramson JL, Vaccarino V. Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults. Arch Intern Med 2002;162:1286-9
Views & Downloads
Abstract views: 2721
PDF (Bahasa Indonesia) downloads: 1989
PDF (Bahasa Indonesia) downloads: 1989
How to Cite
Iskandarsyah, K. (1). The Effects of Short-Term, Low-Intensity Exercise Training on the Levels of High-Sensitive C-Reactive Protein in Patients with Acute Myocardial Infarction. Indonesian Journal of Cardiology, 28(2), 100-105. https://doi.org/10.30701/ijc.v28i2.253
Section
Clinical Research
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
