Mangosteen Pericarp Inhibits Nuclear Factor ?B (NF-?B) Activation and Reduces Expression of ICAM-1 in High Cholesterol Diet Rat

  • H Hendarto Department of Internal Medicine, Department of Cardiology and Vascular Medicine, Dr. Saiful Anwar Hospital/ Faculty of Medicine, Brawijaya University. JL. Jaksa Agung Suprapto 2 Malang, Indonesia
  • Mohammad Saifur Rohman bDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, University of Brawijaya /dr. Saiful Anwar Hospital Malang
  • Djanggan Sargowo Department of Internal Medicine, Department of Cardiology and Vascular Medicine, Dr. Saiful Anwar Hospital/ Faculty of Medicine, Brawijaya University. JL. Jaksa Agung Suprapto 2 Malang, Indonesia

Abstract

Background: Atherosclerosis is widely viewed as an inflammatory disease with hypercholesterolemia being a dominant underlying risk factor. This study aimed to determine the effect of mangosteen pericarp in inhibition of NF-?B activation and ICAM-1 expression in rat fed with high cholesterol.
Methods and Results: Various doses of crude extract mangosteen pericarp were administered to the high fat diet wistar rats and the activity of NF-?B measured by immunohistochemistry to assess nuclear NF-?B expression and the ICAM-1 expression. The high fat diet resulted significant increased serum LDL levels. Increased nuclear NF- ?B activation and ICAM-1 expression were also observed in high fat diet rats in concurrence with increased serum LDL. The inhibitory effect on NF- ?B activity and ICAM-1 expression was observed when 400 mg of mangosteen pericarp crude extract was administered and even showed a higher inhibitory effect in 800 mg of mangosteen pericap treated rats. The 800 mg extract treatment resulted in decreased ICAM-1 expression similar to those of non high fat rats.
Conclusion: The administration of 800 mg mangosteen pericarp crude extract significantly inhibited NF-?B activation and reversed the expression of ICAM -1 to the normal level in high cholesterol diet rats.

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Published
2013-10-16
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How to Cite
Hendarto, H., Rohman, M., & Sargowo, D. (2013). Mangosteen Pericarp Inhibits Nuclear Factor ?B (NF-?B) Activation and Reduces Expression of ICAM-1 in High Cholesterol Diet Rat. Indonesian Journal of Cardiology, 34(1), 23-32. https://doi.org/10.30701/ijc.v34i1.302
Section
Clinical Research