Effect of Mitral Stenosis Severity on Blood Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 Levels
Abstract
Background: Blood Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) and Soluble Intercellular Adhesion Molecule-1 (sICAM-1) levels are increased in Mitral Stenosis (MS) patients, but whether this phenomenon is due to chronic rheumatic inflammation process or because of hemodynamic effect of mitral stenosis severity is not clear yet.Objective: This research aims to study the effect of mitral stenosis severity on blood sVCAM-1 and sICAM-1 levels.
Method: This study is a cross sectional study. Research subjects were divided into 3 groups: control patients, pre BMV (Baloon Mitral Valvulotomy) group, and post BMV group (patients who have already undergone BMV for ? 1year). Blood sVCAM-1 and sICAM-1 were measured using quantitative sandwich immunoassay method in all groups, and echocardiographic study to evaluate MS severity (MVA (Mitral Valve Area), mMVG (mean Mitral Valve gradient), TVG (Tricuspid Valve Gradient), mPAP (mean Pulmonary Artery Pressure), and LAVI (Left Atrial Volume Index) were performed to pre BMV and post BMV group at the same day with the blood sample collections.
Results: There were 23 normal subjects, 26 patients in pre BMV group, and 27 patients in post BMV group. The sVCAM-1 and sICAM-1 levels in patients with MS (pre BMV and post BMV group) were higher than normal control subjects (536,87 ± 251,68 ng/ml vs 536,87 ± 149,22 ng/ml; p<0,001 and 270,04 ± 111,67 ng/ml vs 216,43 ± 50,60 ng/ml; p=0,006), meanwhile there were no differences of sVCAM-1 and sICAM-1 levels between pre BMV and post BMV group (854,67 ± 227,26 ng/ml vs 809,22 ± 275,63 ng/ml; p=0,515 dan 279,98 ± 114,39 ng/ml vs 260,49 ± 110,38 ng/ml; p=0,539). There were also no significant correlation between mitral stenosis severity (MVA, mMVG, TVG, mPAP dan LAVI) with sVCAM-1 and sICAM-1 levels (p>0,05).
Conclusion: There were no correlation between mitral stenosis severity with blood sVCAM-1 and sICAM-1 levels
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References
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Movahed MR, Ahmadi-Kashani M, Kasravi B, Saito Y. Increased prevalence of mitral stenosis in women. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 2006 Jul;19(7):911-3.
Shrivastava S, Dev V, Vasan RS, Das GS, Rajani M. Percutaneous balloon mitral valvuloplasty in juvenile rheumatic mitral stenosis. The American journal of cardiology. 1991 Apr 15;67(9):892-4.
Ahmad S, Hayat U, Naz H. Frequency of severe mitral stenosis in young female patients having pure mitral stenosis secondary to rheumatic heart disease. Journal of Ayub Medical College, Abbottabad : JAMC. 2010 Oct-Dec;22(4):19-22.
Bisno A, Butchart EG, Ganguly N, Ghebrehiwet T, Lue H-C, Kaplan EL, et al. Epidemiology of group A streptococci, rheumatic fever and rheumatic heart disease in WHO Expert Consultation on Rheumatic Fever and Rheumatic Heart Disease. Geneva: WHO, 2001 Contract No.: 923.
Kuncoro AS. Pemeriksaan Stenosis Mitral Akibat Proses Rheumatik Dengan Ekokardiografi. Jurnal Kardiologi Indonesi. 2010;31(1):62-5.
Yusak M. Stenosis mitral In: Rilantono LI, Baraas F, Karo SK, Roebiono PS, editors. Buku Ajar Kardiologi. 1 ed. Jakarta: Balai Penerbit Fakultas Kedokteran Universitas Indonesia; 2003. p. 135-44.
Chen MC, Chang HW, Juang SS, Yip HK, Wu CJ, Yu TH, et al. Percutaneous transluminal mitral valvuloplasty reduces circulating vascular cell adhesion molecule-1 in rheumatic mitral stenosis. Chest. 2004 Apr;125(4):1213-7.
Chen MC, Wu CJ, Yip HK, Chang HW, Fang CY, Yu TH, et al. Left atrial platelet activity with rheumatic mitral stenosis: correlation study of severity and platelet P-selectin expression by flow cytometry. Chest. 2003 Nov;124(5):1663-9..
Yetkin E, Erbay AR, Ileri M, Turhan H, Balci M, Cehreli S, et al. Levels of circulating adhesion molecules in rheumatic mitral stenosis. The American journal of cardiology. 2001 Nov 15;88(10):1209-11.
Yetkin E, Erbay AR, Turhan H, Balci M, Yetkin F, Yetkin G, et al. Changes in plasma levels of adhesion molecules after percutaneous mitral balloon valvuloplasty. Cardiovasc Pathol. 2004 Mar-Apr;13(2):103-8.
Roberts S, Kosanke S, Terrence Dunn S, Jankelow D, Duran CM, Cunningham MW. Pathogenic mechanisms in rheumatic carditis: focus on valvular endothelium. J Infect Dis. 2001 Feb 1;183(3):507-11.
Saikia UN, Kumar RM, Pandian VK, Gupta S, Dhaliwal RS, Talwar KK. Adhesion molecule expression and ventricular remodeling in chronic rheumatic heart disease: a cause or effect in the disease progression--a pilot study. Cardiovasc Pathol. 2012 Mar-Apr;21(2):83-8.
Carabello BA. Modern management of mitral stenosis. Circulation. 2005 Jul 19;112(3):432-7.
Fadhilah A, Rahajoe AU, Kasim M. Atorvastatin Memodulasi Ekspresi Gen Tumor Necrosis Factor-?, Interferon-? dan Interleukin-4 Pada Jaringan Katup dan Appendiks Atrium Kiri Penderita Penyakit Jantung Reumatik Jakarta: Universitas Indonesia; 2013.
Antonini-Canterin F, Hirsu M, Popescu BA, Leiballi E, Piazza R, Pavan D, et al. Stage-related effect of statin treatment on the progression of aortic valve sclerosis and stenosis. Am J Cardiol. 2008 Sep 15;102(6):738-42.
Dahlan MS. Kesalahan Tipe I, TIpe II, Power, dan Hipotesis Penelitian. Besar sampel dan cara pengambilan sampel dalam Penelitian Kedokteran dan Kesehatan. Jakarta: Salemba Medika; 2013. p. 24-33.
Movahed MR, Ahmadi-Kashani M, Kasravi B, Saito Y. Increased prevalence of mitral stenosis in women. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 2006 Jul;19(7):911-3.
Shrivastava S, Dev V, Vasan RS, Das GS, Rajani M. Percutaneous balloon mitral valvuloplasty in juvenile rheumatic mitral stenosis. The American journal of cardiology. 1991 Apr 15;67(9):892-4.
Ahmad S, Hayat U, Naz H. Frequency of severe mitral stenosis in young female patients having pure mitral stenosis secondary to rheumatic heart disease. Journal of Ayub Medical College, Abbottabad : JAMC. 2010 Oct-Dec;22(4):19-22.
Bisno A, Butchart EG, Ganguly N, Ghebrehiwet T, Lue H-C, Kaplan EL, et al. Epidemiology of group A streptococci, rheumatic fever and rheumatic heart disease in WHO Expert Consultation on Rheumatic Fever and Rheumatic Heart Disease. Geneva: WHO, 2001 Contract No.: 923.
Published
2015-03-31
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How to Cite
Sigit, P., Yuniadi, Y., & Sakidjan, I. (2015). Effect of Mitral Stenosis Severity on Blood Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 Levels. Indonesian Journal of Cardiology, 35(1), 14-21. https://doi.org/10.30701/ijc.v35i1.371
Section
Clinical Research
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