Metabolism changes and the role of the free radicals on myocardial ischemia
Abstract
Myocardial ischemic results from severe impairment of coronary blood supply and produces a spectrum of clinical syndromes. It results in a characteristic pattern of metabolic and structural changes that leads to extremely complex situations, which have been extensively studied in recent years. A detailed understanding is now available of the complexity of the response of the myocardium to an ischemic insult. Reperfusion is the most effective way to treat the ischaemic myocardial. But, restoration of flow, however, might result in numerous other negative consequences, thus directly influencing the degree of recovery. Much evidence shows that during the period of myocardial ischemia and reperfusion can occur various changes both in terms of metabolic, electrical, histology, structural, and physiological. Pathological changes in the form of metabolic changes and the role of free radicals on the condition of ischemia and reperfusion injury will be discussed. There are several potential manifestations and outcomes associated with myocardial ischemia and reperfusion.Downloads
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References
Ferrari R, Pepi P, Ferrari F, Nesta F, Benigno M, Visioli O. Metabolic Derangement in Ischemic Heart Disease and Its Therapeutic Control. Am J Cardiol 1998;82:2K-13K.
Frank A, Bonney M, Bonney S, Weitzel L, Koeppen M, Eckle T. Myocardial Ischemia Reperfusion Injury: From Basic Science to Clinical Bedside. Seminars in Cardiothoracic and Vascular Anesthesia. 2012;16(3):123-132.
Kutala VK, Khan M, Angelos MG, Kuppusamy P. Role of Oxygen in Postischemic Myocardial Injury. Antioxidants & Redox Signaling. 2007;9(8):1193-1206.
Jennings RB, Reimer KA. Lethal Myocardial Ischemic Injury. AmJ Pathol. 1981;102:241-255.
Bainey KR, Armstrong PW, Alberta. Clinical perspectives on reperfusion injury in acute myocardial infarction. Am Heart J 2014;0:1-9.
Jennings RB. Historical Perspective on the Pathology of Myocardial Ischemia/Reperfusion Injury. Circ Res. 2013;113:428-438.
Gourdin M, Dubois P. Impact of Ischemia on Cellular Metabolism. In: Aronow WS, ed. Artery Bypass. Belgium: InTech; 2013.
Buja LM. Coronary Artery Disease: Pathological Anatomy and Pathogenesis. In: Willerson JT, Jr DRH, eds. Coronary Artery Disease. London: Springer London; 2015:1-20.
Buja LM. Myocardial ischemia and reperfusion injury. Cardiovascular Pathology 2005;14:170- 175.
Yellon DM, Downey JM. Preconditioning the Myocardium : From Cellular Physiology to Clinical Cardiology. Physiol Rev 2003;83:1113-1151.
Ferrari R, Ceconi C, Curello S, Alfierii O, Visioli O. Myocardial damage during ischaemia and reperfusion. European Heart Journal. 1993;14 (Supplement G):25-30.
Gutowski M, Kowalczyk S. A study of free radical chemistry: their role and pathophysiological significance. Acta Biochimica Polonica. 2013;60(1):1-16.
Young CP, Williams BT. Free radicals and myocardial injury. Pakistan Heart Journal. 1990;23(2):27-33.
Shah AM, Channon KM. Free radicals and redox signalling in cardiovascular disease. Heart. 2004;90:486-487.
Hearse DJ. Free radicals and myocardial injury during ischemia and reperfusion : a short-lived phenomenon In: Rosen MR, Palti Y, eds. Lethal arrhythmias resulting from myocardial ischemia and infarction. Boston/Dordrecht/London: Kluwers Academic Publisher; 1989:105-115.
Ferrari R. Oxygen free radicals at myocardial level : Effects of ischaemia and reperfusion. In: Armstrong D, ed. Free Radicals in Diagnostic Medicine. New York: Plenum Press; 1994:99-111.
Lisa FD, Bernardi P. Mitochondria and ischemia–reperfusion injury of the heart: Fixing a hole. Cardiovascular Research 2006;70:191 - 199.
Stride N, Larsen S, Hey-Mogensen M, Hansen CN, Prats C, Steinbrüchel D. Impaired mitochondrial function in chronically ischemic human heart. Am J Physiol Heart Circ Physiol. 2013;304:H1407-H1414.
Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL. Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure. J Mol Cell Cardiol 2001;33:1065-1089.
Frank A, Bonney M, Bonney S, Weitzel L, Koeppen M, Eckle T. Myocardial Ischemia Reperfusion Injury: From Basic Science to Clinical Bedside. Seminars in Cardiothoracic and Vascular Anesthesia. 2012;16(3):123-132.
Kutala VK, Khan M, Angelos MG, Kuppusamy P. Role of Oxygen in Postischemic Myocardial Injury. Antioxidants & Redox Signaling. 2007;9(8):1193-1206.
Jennings RB, Reimer KA. Lethal Myocardial Ischemic Injury. AmJ Pathol. 1981;102:241-255.
Bainey KR, Armstrong PW, Alberta. Clinical perspectives on reperfusion injury in acute myocardial infarction. Am Heart J 2014;0:1-9.
Jennings RB. Historical Perspective on the Pathology of Myocardial Ischemia/Reperfusion Injury. Circ Res. 2013;113:428-438.
Gourdin M, Dubois P. Impact of Ischemia on Cellular Metabolism. In: Aronow WS, ed. Artery Bypass. Belgium: InTech; 2013.
Buja LM. Coronary Artery Disease: Pathological Anatomy and Pathogenesis. In: Willerson JT, Jr DRH, eds. Coronary Artery Disease. London: Springer London; 2015:1-20.
Buja LM. Myocardial ischemia and reperfusion injury. Cardiovascular Pathology 2005;14:170- 175.
Yellon DM, Downey JM. Preconditioning the Myocardium : From Cellular Physiology to Clinical Cardiology. Physiol Rev 2003;83:1113-1151.
Ferrari R, Ceconi C, Curello S, Alfierii O, Visioli O. Myocardial damage during ischaemia and reperfusion. European Heart Journal. 1993;14 (Supplement G):25-30.
Gutowski M, Kowalczyk S. A study of free radical chemistry: their role and pathophysiological significance. Acta Biochimica Polonica. 2013;60(1):1-16.
Young CP, Williams BT. Free radicals and myocardial injury. Pakistan Heart Journal. 1990;23(2):27-33.
Shah AM, Channon KM. Free radicals and redox signalling in cardiovascular disease. Heart. 2004;90:486-487.
Hearse DJ. Free radicals and myocardial injury during ischemia and reperfusion : a short-lived phenomenon In: Rosen MR, Palti Y, eds. Lethal arrhythmias resulting from myocardial ischemia and infarction. Boston/Dordrecht/London: Kluwers Academic Publisher; 1989:105-115.
Ferrari R. Oxygen free radicals at myocardial level : Effects of ischaemia and reperfusion. In: Armstrong D, ed. Free Radicals in Diagnostic Medicine. New York: Plenum Press; 1994:99-111.
Lisa FD, Bernardi P. Mitochondria and ischemia–reperfusion injury of the heart: Fixing a hole. Cardiovascular Research 2006;70:191 - 199.
Stride N, Larsen S, Hey-Mogensen M, Hansen CN, Prats C, Steinbrüchel D. Impaired mitochondrial function in chronically ischemic human heart. Am J Physiol Heart Circ Physiol. 2013;304:H1407-H1414.
Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL. Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure. J Mol Cell Cardiol 2001;33:1065-1089.
Published
2016-03-03
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How to Cite
Sarvasti, D. (2016). Metabolism changes and the role of the free radicals on myocardial ischemia. Indonesian Journal of Cardiology, 36(3), 162-7. https://doi.org/10.30701/ijc.v36i3.480
Section
Review Article
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