Buah Manggis: the Queen of Fruit
Abstract
Ketidak-keseimbangan antara radikal bebas dan antioksidan kini diketahui sebagai penyebab utama dari berbagaipenyakit degeneratif, seperti kanker dan penyakit jantung. Akumulasi radikal bebas yang berlebihan dapat menyebabkan peroksidasi lipid, pro-tein dan DNA di dalam inti sel. Stres oksidatif adalah ketidak-seimbangan antara produksi radikal bebas oksigen dengan antioksidan yang tersedia di dalam sel.Dalam hal-hal tertentu, produksi radikal bebas oksigen dapat meningkat, sementara antioksi dan yang tersedia tidak mencukupi untuk menetralisirnya. Pada orang-orang yang beranjak tua, kecenderungan itulah yang mudah terjadi, dimana produksi radikal bebas oksigen cenderung meningkat dengan meningkatnya usia, sementara produksi antioksidan di dalam sel ataupun asupan antioksi dan dari luar seringkali sudah mulai cenderung berkurang.
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References
Faisal Baraas. Kardiologi Molekuler. Radikal Bebas, Disfungsi Endotel, Aterosklerosis, Antioksidan, Latihan Fisik, dan Rehabilitasi Jantung. Penerbit Kardia Ikratama, Jakarta, 2006.
Weecharangsan W, Opanasopit P, Sukma M, et al. Antioxidative and neuroprotectiveactivites of extracts from the fruit hull of mangosteen (garciniamangostanalinn). Med Princ Pract 2006; 15:281-287.
Ho C, Huang YL, Chen CC. Garcinone E, a xanthone deriva tive, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta Med 2002;68:975-979.
http://www.wikipedia.org. 5. Jung HA, Su BN, Keller WJ, Mehta RG, and Kinghorn AD. Antioxidant Xanthones from the Pericarp of Garciniamangostana (Mangosteen). J. Agric. Food Chem., 2006;54(6):2077.
Bumrungpert A, Kalpravidh RW, Chitchumroonchokchai C, Chuang CC, West T, Kennedy A, and McIntosh M. Xanthones from Mangosteen Prevent Lipopolysaccharide-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes. J. Nutr. 2009;139:1185.
Bumrungpert A, Kalpravidh RW, Chuang CC, Overman A, Martinez K, Kennedy A, and McIntosh M. Xanthones from Mangosteen Inhibit Inflammation in Human Macrophages and in Human Adipocytes Exposed to Macrophage-Conditioned Media. J. Nutr. 2010;140:842.
Johnson JJ, Petiwala SM, Syed DN, Rasmussen JT, Adhami VM, SiddiquiIA, KohlAM, and Mukhtar H. a-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth. Carcinogenesis 2012;33:413.
Hafiselvi MD, Setiawan M, Sargowo D. Effect of Extract From Pericarp of Mangosteen (Garcinia Mangostana Linn) as Antioxidant in Rats Models of Atherosclerosis. J Kardiol Indones. 2012; 32:75-80
Weecharangsan W, Opanasopit P, Sukma M, et al. Antioxidative and neuroprotectiveactivites of extracts from the fruit hull of mangosteen (garciniamangostanalinn). Med Princ Pract 2006; 15:281-287.
Ho C, Huang YL, Chen CC. Garcinone E, a xanthone deriva tive, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta Med 2002;68:975-979.
http://www.wikipedia.org. 5. Jung HA, Su BN, Keller WJ, Mehta RG, and Kinghorn AD. Antioxidant Xanthones from the Pericarp of Garciniamangostana (Mangosteen). J. Agric. Food Chem., 2006;54(6):2077.
Bumrungpert A, Kalpravidh RW, Chitchumroonchokchai C, Chuang CC, West T, Kennedy A, and McIntosh M. Xanthones from Mangosteen Prevent Lipopolysaccharide-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes. J. Nutr. 2009;139:1185.
Bumrungpert A, Kalpravidh RW, Chuang CC, Overman A, Martinez K, Kennedy A, and McIntosh M. Xanthones from Mangosteen Inhibit Inflammation in Human Macrophages and in Human Adipocytes Exposed to Macrophage-Conditioned Media. J. Nutr. 2010;140:842.
Johnson JJ, Petiwala SM, Syed DN, Rasmussen JT, Adhami VM, SiddiquiIA, KohlAM, and Mukhtar H. a-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth. Carcinogenesis 2012;33:413.
Hafiselvi MD, Setiawan M, Sargowo D. Effect of Extract From Pericarp of Mangosteen (Garcinia Mangostana Linn) as Antioxidant in Rats Models of Atherosclerosis. J Kardiol Indones. 2012; 32:75-80
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How to Cite
Baraas, F. (1). Buah Manggis: the Queen of Fruit. Indonesian Journal of Cardiology, 33(2), 81-2. https://doi.org/10.30701/ijc.v33i2.56
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