Left Ventricle Function Alterations in HIV-infected Patients
Abstract
Background. Patients with HIV have increased risk for myocardial dysfunction but the underlying mechanisms remain unknown.Methods & Results. This study evaluated noninvasively ventricular function in HIV infected patients with no clinical evidence of cardiovascular disease, with determination of left ventricular systolic and diastolic function, as well as measurement of CD 4. Between November 2009 and June 2010, 22 patients agreed to participate in a follow up study. All patients had normal LVEF and FS at both examinations. There was no evidence for a relationship between LVEF changes and either CD 4 changes, CD 4 nadir and HIV stadium. However an increase in mean EPSS was observed at follow up (p=0.045) and associated with lower CD 4 cell counts. At the initial visit, 1 patient had left ventricular dysfunction, and 4 patients at follow up. All patients had normal TAPSE values at both examinations.
Conclusion. HIV related cardiomyopathy appears not to constitute a problem in HAART era. However subclinical cardiac abnormalities are frequently observed. The usefulness of systematic noninvasive screening in this population should be considered.
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References
Khunnawat C, Mukerji S, Havlichek D, et al. Cardiovascular Manifestations in Human Immunodeficiency Virus-Infected Patients. Am J Cardiol 2008; 102:635-642.
Zipes DP, Libby P, Bonow RO, et al, editors. Braunwald’s Heart Disease A Textbook of Cardiovascular Medicine. 7thed. Philadelphia: Elsevier Saunders, 2005.
Murphy JG, Lloyd MA, editors. Mayo Clinic Cardiology. 3rd ed. Minnesota: Mayo Clinic Scientific Press.
Schuster I, Thoni GJ, Edhery S, et al. Subclinial Cardiac Abnormalities in Human Immunodeficiency Virus-Infected Men Receiving Antiretroviral Therapy. Am J Cardiol 2008; 101:1213-1217.
Lebech AM, Gerstoft J, Hesse B, et al. Right and Left ventricular function in a developed world population with human immunodeficiency virus studied with radionuclide ventriculography. Am Heart J 2004; 147:482-8.
Barbaro G, Boccara F, editors. Cardiovascular Disease in AIDS. Verlag: Springer, 2005.
Barbaro G. Cardiovascular Manifestations of HIV infection. Circulation 2002; 106:1420-1425.
Barbaro G, Lorenzo GD, Grisorio B, et al. Incidence of Dilated Cardiomyopathy and detection of HIV in myocardial cells of HIV-positive patients. N Engl J Med 2002; 347(2):140.
Castro SD, d’Amati G, Gallo P. et al. Frequency of development of acute global left ventricular dysfunction in human immuno-deficiency virus infection. J Am Coll Cardiol 1994;24:1018-24.
Blanchard DG, Hagenhoff C, Chow LC, et al. Reversibility of cardiac abnormalities in human immunodeficiency virus(HIV)-infected individuals: a serial echocardiographic study. J Am Coll Cardiol 1991;17(6):1270-6.
Venkat A, Piontkowsky DM, Cooney RR, et al. Care of the HIV-positive in the emergency department in the era of highly active antiretroviral therapy. Ann Emerg Med 2008;52:274-285.
Sudano I, Spieker LE, Noll G, et al. Cardiovascular disease in HIV infection. Am Heart J 2006;151:1147-55.
Cardoso JS, Moura B, Martins L, et al. Left ventricular dysfunction in human immunodeficiency virus (HIV)-infected patients. International journal of cardiology 1998;63:37-45.
Hsue PY, Hunt PW, Ho JE, et al. Impact of HIV infection on diastolic function and left ventricular mass. Circulation 2010;3:132-139.
Kristoffersen US, Lebech AM, Gerstoft J, et al. Right and left cardiac function in HIV-infected patients investigated using radionuclide ventriculography and brain natriuretic peptide: a five year follow up study. HIV medicine 2008;9:180-186.
Anderson B. The normal examination and echocardiographic measurements. 2nd ed. Brisbane: Elsevier Saunders, MGA graphics 2007.
Currie PF, Jacob AJ, Foreman AR, et al. Heart muscle disease related to HIV infection: prognostic implications. BMJ 1994;309:1605-1607
Solomon SD, editor. Essential echocardiography. New Jersey: Humana Press, 2007
Werneck GL, Mesquita ET, Romeo LJM, et al. Doppler echocardiographic evaluation oh HIV-positive patients in difference stages of diseases. Arq Bras Cardiol 1999;73:163-168.
Escaut L, Monsuez JJ, Chironi G, et al. Coronary artery disease in HIV-infected patients. Intensive care med 2003;29:969-973.
Zipes DP, Libby P, Bonow RO, et al, editors. Braunwald’s Heart Disease A Textbook of Cardiovascular Medicine. 7thed. Philadelphia: Elsevier Saunders, 2005.
Murphy JG, Lloyd MA, editors. Mayo Clinic Cardiology. 3rd ed. Minnesota: Mayo Clinic Scientific Press.
Schuster I, Thoni GJ, Edhery S, et al. Subclinial Cardiac Abnormalities in Human Immunodeficiency Virus-Infected Men Receiving Antiretroviral Therapy. Am J Cardiol 2008; 101:1213-1217.
Lebech AM, Gerstoft J, Hesse B, et al. Right and Left ventricular function in a developed world population with human immunodeficiency virus studied with radionuclide ventriculography. Am Heart J 2004; 147:482-8.
Barbaro G, Boccara F, editors. Cardiovascular Disease in AIDS. Verlag: Springer, 2005.
Barbaro G. Cardiovascular Manifestations of HIV infection. Circulation 2002; 106:1420-1425.
Barbaro G, Lorenzo GD, Grisorio B, et al. Incidence of Dilated Cardiomyopathy and detection of HIV in myocardial cells of HIV-positive patients. N Engl J Med 2002; 347(2):140.
Castro SD, d’Amati G, Gallo P. et al. Frequency of development of acute global left ventricular dysfunction in human immuno-deficiency virus infection. J Am Coll Cardiol 1994;24:1018-24.
Blanchard DG, Hagenhoff C, Chow LC, et al. Reversibility of cardiac abnormalities in human immunodeficiency virus(HIV)-infected individuals: a serial echocardiographic study. J Am Coll Cardiol 1991;17(6):1270-6.
Venkat A, Piontkowsky DM, Cooney RR, et al. Care of the HIV-positive in the emergency department in the era of highly active antiretroviral therapy. Ann Emerg Med 2008;52:274-285.
Sudano I, Spieker LE, Noll G, et al. Cardiovascular disease in HIV infection. Am Heart J 2006;151:1147-55.
Cardoso JS, Moura B, Martins L, et al. Left ventricular dysfunction in human immunodeficiency virus (HIV)-infected patients. International journal of cardiology 1998;63:37-45.
Hsue PY, Hunt PW, Ho JE, et al. Impact of HIV infection on diastolic function and left ventricular mass. Circulation 2010;3:132-139.
Kristoffersen US, Lebech AM, Gerstoft J, et al. Right and left cardiac function in HIV-infected patients investigated using radionuclide ventriculography and brain natriuretic peptide: a five year follow up study. HIV medicine 2008;9:180-186.
Anderson B. The normal examination and echocardiographic measurements. 2nd ed. Brisbane: Elsevier Saunders, MGA graphics 2007.
Currie PF, Jacob AJ, Foreman AR, et al. Heart muscle disease related to HIV infection: prognostic implications. BMJ 1994;309:1605-1607
Solomon SD, editor. Essential echocardiography. New Jersey: Humana Press, 2007
Werneck GL, Mesquita ET, Romeo LJM, et al. Doppler echocardiographic evaluation oh HIV-positive patients in difference stages of diseases. Arq Bras Cardiol 1999;73:163-168.
Escaut L, Monsuez JJ, Chironi G, et al. Coronary artery disease in HIV-infected patients. Intensive care med 2003;29:969-973.
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How to Cite
Lubis, A., Siregar, A., & Kasiman, S. (1). Left Ventricle Function Alterations in HIV-infected Patients. Indonesian Journal of Cardiology, 33(5), 21-7. https://doi.org/10.30701/ijc.v33i5.72
Section
Clinical Research
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