Mechanisms of Atrial Fibrillation in Hyperthyoid

  • Wenny Fitrina Dewi Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia National Cardiovascular Center Harapan Kita, Jakarta
  • Yoga Yuniadi Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia National Cardiovascular Center Harapan Kita, Jakarta


Atrial fibrillation (AF) is the most common cardiac arrhythmia other than sinus tachycardia encountered in hyperthyroidism and representing an independent risk factor for cardiovascular event. Atrial fibrillation occurs in 10-15% of patient with hyperthyroidism, where as prevalence increase with advancing age. The heart is a major target organ for thyroid hormone action. Thyroid hormones exert their cardiovascular effects either directly at cardiomiosit through nuclear receptors (gen transcription) and extra nuclear (cellular) which is influence inotropic, chronotropic and dromotropic effect and indirectly by influencing sympatoadrenergic system and altering peripheral hemodynamic. Hyperthyroidism is associated with an increased supraventricular ectopic activity. Hyperthyroidism increases the rate of systolic depolarization and diastolic repolarization, decreases the duration of the action potential and refraction period of the atrial myocardium, as well as atrioventricular nodal therefore facilitated the occurrence of atrial fibrillation.


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How to Cite
Dewi, W., & Yuniadi, Y. (1). Mechanisms of Atrial Fibrillation in Hyperthyoid. Indonesian Journal of Cardiology, 32(3), 192-8.
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