Sel Punca Pada Penyakit Kardiovaskular: Kembali ke Bench

Suko Adiarto

doi:10.30701/ijc.v31i2.137

Suko Adiarto Departemen Kardiologi dan Kedok-teran Vaskular FKUI, dan Pusat Jantung Nasional Harapan Kita, Jakarta

DOI: https://doi.org/10.30701/ijc.v31i2.137

Abstract

Ungkapan from bench to bedside sesungguhnya merupakan dambaan setiap peneliti yang bergerak dalam ilmu-ilmu dasar kardiovaskular, dimana penemuan yang mereka hasilkan dari laboratorium pada tingkat kultur sel sampai uji efektitivitasnya pada hewan coba dengan model penyakit kardiovaskular dapat men-emukan aplikasi klinik yang bermanfaat. Tidak semua temuan yang secara teoritis menjanjikan pada tingkat laboratorium maupun hewan coba dapat menunjukan efektivitas yang diharapkan pada uji klinik. Bahkan, ketika suatu modalitas yang secara meyakinkan menunjukkan potensi terapetik yang baik pada pe-nelitian laboratorium atau hewan coba, namun gagal pada tingkat uji klinik seringkali diuji kembali pada penelitian laboratorium untuk mencari pemecahan dari kegagalan pada uji klinik tersebut.

Downloads

Download data is not yet available.

References

News in Brief: Stem-cell society condemns medical tourism. Nature. 2008; 453:969.

Passier R, Vaan Laake LW, Mummery CL. Stem cell-based therapy and lessons from the heart. Nature. 2008;453:322-9.

Rechman J, Feeling the Elephant in Cardiovascular Cell Therapy. Circulation. 2010; 121:197-9.

Segers VF, Lee RT. Stem cell therapy for cardiac disease. Nature. 2008;451:937-42.

Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors.Science. 2008;322:949-53.

Yoshida Y, Yamanaka S. Recent stem cell advances: induced pluripotent stem cells for disease modeling and stem cell-based regeneration.Circulation. 2010;122:80-7.

Orlic D, Kajstura J, Chimenti S, Bodine DM, Leri A, Anversa P. Bone marrow cell regenerate infracted myocardium. Pediatric Transplantation. 2003;7:86-8

Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR. Turning blood into brain: cells bearing neuronal antigens gener-ated in vivo from bone marrow. Science.2000;290:1779-82.

Jensen GS, Hart AN, Zaske LA, Drapeau C, Gupta N, Schaeffer DJ, Cruickshank JA. Mobilization of human CD34+ CD133+ and CD34+ CD133(-) stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae--related to modulation of CXCR4 expression by an L-selectin ligand?Cardiovasc Revasc Med. 2007;8:189-202.

Drapeau C, Antarr D, Ma H, Yang Z, Tang L, Hoffman RM, Schaeffer DJ. Mobilization of bone marrow stem cells with StemEnhance improves muscle regeneration in cardiotoxin-induced muscle injury.Cell Cycle;9:1819-23.

Jensen GS, Drapeau C. The use of in situ bone marrow stem cells for the treatment of various degenerative diseases.Med Hypotheses. 2002;59:422-8.

Pasha Z, Wang Y, Sheikh R, Zhang D, Zhao T, Ashraf M. Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium. Cardiovasc Res. 2008;77:134-42.

Yu J, Li M, Qu Z, Yan D, Li D, Ruan Q. SDF-1/CXCR4-mediated migration of transplanted bone marrow stromal cells toward areas of heart myocardial infarction through activation of PI3K/Akt.J Cardiovasc Pharmacol. 2010;55:496-505.

Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, Böhm M, Nickenig G.Circulating endothelial progenitor cells and cardiovascular outcomes.N Engl J Med. 2005;353:999-1007.

Persons DA, Allay JA, Allay ER, Smeyne RJ, Ashmun RA, Sorrentino BP, Nienhuis AW. Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo. Blood. 1997;90:1777-86.