An effort to find biomarker for micro-vascular obstruction in patient with myocardial infarction undergoing primary revascularization: is fibrinogen the answer?
Abstract
Meski revaskularisasi telah menunjukkan manfaat besar dalam menurunkan morbiditas dan mortalitas pada pasien infark miokard akut dengan elevasi segmen ST (IMA-EST), manfaat dari intervensi koroner perkutan primer (IKPP) yang berhasil mengembalikan aliran koroner epikardial seringkali tidak optimal di tingkat mikro sirkulasi karena adanya obstruksi mikrovaskular.Obstruksi mikrovaskular (OMV) berperan penting dalam menentukan prognosis pasien paska tindakan,1, 2 dan telah dilaporkan bahwa keberadaan obstruksi mikro-vaskular berkorelasi dengan penurunan survival pasien paska IMA-EST, melalui pengaruhnya pada proses remodeling ventrikel.3, 4
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References
1. Gibson CM, Cannon CP, Murphy SA, Ryan KA, Mesley R, Marble SJ, McCabe CH, Van De Werf F, Braunwald E. Relationship of timi myocardial perfusion grade to mortality after administration of thrombolytic drugs. Circulation. 2000;101:125-130
2. Michaels AD, Gibson CM, Barron HV. Microvascular dysfunction in acute myocardial infarction: Focus on the roles of platelet and inflammatory mediators in the no-reflow phenomenon. The American journal of cardiology. 2000;85:50B-60B
3. Gerber BL, Rochitte CE, Melin JA, McVeigh ER, Bluemke DA, Wu KC, Becker LC, Lima JA. Microvascular obstruction and left ventricular remodeling early after acute myocardial infarction. Circulation. 2000;101:2734-2741
4. Wu KC, Zerhouni EA, Judd RM, Lugo-Olivieri CH, Barouch LA, Schulman SP, Blumenthal RS, Lima JA. Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation. 1998;97:765-772
5. Payne AR, Berry C, Doolin O, McEntegart M, Petrie MC, Lindsay MM, Hood S, Carrick D, Tzemos N, Weale P, McComb C, Foster J, Ford I, Oldroyd KG. Microvascular resistance predicts myocardial salvage and infarct characteristics in st-elevation myocardial infarction. Journal of the American Heart Association. 2012;1:e002246
6. Fearon WF, Low AF, Yong AS, McGeoch R, Berry C, Shah MG, Ho MY, Kim HS, Loh JP, Oldroyd KG. Prognostic value of the index of microcirculatory resistance measured after primary percutaneous coronary intervention. Circulation. 2013;127:2436-2441
7. Younger JF, Plein S, Barth J, Ridgway JP, Ball SG, Greenwood JP. Troponin-i concentration 72 h after myocardial infarction correlates with infarct size and presence of microvascular obstruction. Heart. 2007;93:1547-1551
8. Ko YG, Won H, Shin DH, Kim JS, Kim BK, Choi D, Hong MK, Bae JH, Lee S, Lim DS, Jang Y. Efficacy of early intensive rosuvastatin therapy in patients with st-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (rosemary study). The American journal of cardiology. 2014;114:29-35
9. Nazir SA, Khan JN, Mahmoud IZ, Greenwood JP, Blackman DJ, Kunadian V, Been M, Abrams KR, Wilcox R, Adgey AA, McCann GP, Gershlick AH. The reflo-stemi trial comparing intracoronary adenosine, sodium nitroprusside and standard therapy for the attenuation of infarct size and microvascular obstruction during primary percutaneous coronary intervention: Study protocol for a randomised controlled trial. Trials. 2014;15:371
10. Heusch G, Botker HE, Przyklenk K, Redington A, Yellon D. Remote ischemic conditioning. Journal of the American College of Cardiology. 2015;65:177-195
2. Michaels AD, Gibson CM, Barron HV. Microvascular dysfunction in acute myocardial infarction: Focus on the roles of platelet and inflammatory mediators in the no-reflow phenomenon. The American journal of cardiology. 2000;85:50B-60B
3. Gerber BL, Rochitte CE, Melin JA, McVeigh ER, Bluemke DA, Wu KC, Becker LC, Lima JA. Microvascular obstruction and left ventricular remodeling early after acute myocardial infarction. Circulation. 2000;101:2734-2741
4. Wu KC, Zerhouni EA, Judd RM, Lugo-Olivieri CH, Barouch LA, Schulman SP, Blumenthal RS, Lima JA. Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation. 1998;97:765-772
5. Payne AR, Berry C, Doolin O, McEntegart M, Petrie MC, Lindsay MM, Hood S, Carrick D, Tzemos N, Weale P, McComb C, Foster J, Ford I, Oldroyd KG. Microvascular resistance predicts myocardial salvage and infarct characteristics in st-elevation myocardial infarction. Journal of the American Heart Association. 2012;1:e002246
6. Fearon WF, Low AF, Yong AS, McGeoch R, Berry C, Shah MG, Ho MY, Kim HS, Loh JP, Oldroyd KG. Prognostic value of the index of microcirculatory resistance measured after primary percutaneous coronary intervention. Circulation. 2013;127:2436-2441
7. Younger JF, Plein S, Barth J, Ridgway JP, Ball SG, Greenwood JP. Troponin-i concentration 72 h after myocardial infarction correlates with infarct size and presence of microvascular obstruction. Heart. 2007;93:1547-1551
8. Ko YG, Won H, Shin DH, Kim JS, Kim BK, Choi D, Hong MK, Bae JH, Lee S, Lim DS, Jang Y. Efficacy of early intensive rosuvastatin therapy in patients with st-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (rosemary study). The American journal of cardiology. 2014;114:29-35
9. Nazir SA, Khan JN, Mahmoud IZ, Greenwood JP, Blackman DJ, Kunadian V, Been M, Abrams KR, Wilcox R, Adgey AA, McCann GP, Gershlick AH. The reflo-stemi trial comparing intracoronary adenosine, sodium nitroprusside and standard therapy for the attenuation of infarct size and microvascular obstruction during primary percutaneous coronary intervention: Study protocol for a randomised controlled trial. Trials. 2014;15:371
10. Heusch G, Botker HE, Przyklenk K, Redington A, Yellon D. Remote ischemic conditioning. Journal of the American College of Cardiology. 2015;65:177-195
Published
2015-11-21
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How to Cite
Widyantoro, B. (2015). An effort to find biomarker for micro-vascular obstruction in patient with myocardial infarction undergoing primary revascularization: is fibrinogen the answer?. Indonesian Journal of Cardiology, 35(3), 147-9. https://doi.org/10.30701/ijc.v35i3.425
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